INTA - Speisky, Hernán

Revistas Internacionales
2010	Carrasco-Pozo C, Gotteland M, Speisky H. Protection by apple peel polyphenols against indomethacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 Cells. J Pharmacy Pharmacol 2010; 62: 943-50
2009	Espinoza M, Olea-Azar C, Speisky H, Rodríguez J. Determination of reactions between free radicals and selected Chilean wines and transition metals by ESR and UV-vis technique. Spectrochim Acta A Mol Biomol Spectrosc 2009; 71(5):1638-1643
2009	Speisky H, Gómez M, Burgos-Bravo F, López-Alarcón C, Jullian C, Olea-Azar C, Aliaga ME. Generation of superoxide radicals by copper-glutathione complexes: Redox-consequences associated with their interaction with reduced glutathione. Bioorg Med Chem 2009; 17(5):1803-1810
2009	Pastene E, Troncoso M, Figueroa G, Alarcón J, Speisky H. Association between polymerization degree of apple peel polyphenols and inhibition of Helicobacter pylori urease. J Agric Food Chem 2009; 57(2):416-424
2009	Pastene E, Speisky H, Troncoso M, Alarcón J, Figueroa G. In vitro inhibitory effect of apple peel extract on the growth of Helicobacter pylori and respiratory burst induced on human neutrophils. J Agric Food Chem 2009; 57(17):7743-7749
2008	Henríquez C, Carrasco-Pozo C, Gómez M, Brunser O, Speisky H. Slow and fast-reacting antioxidants from berries: Their evaluation through the FRAP (Ferric reducing antioxidant power) assay. Acta Hort 2008; 777:531-536
2008	Gotteland M, Andrews M, Toledo M, Muñoz L, Caceres P, Anziani A, Wittig E, Speisky H, Salazar G. Modulation of Helicobacter pylori colonization with cranberry juice and Lactobacillus johnsonii La1 in children. Nutrition 2008; 24(5):421-426
2008	Carrasco-Pozo C, Aliaga ME, Olea-Azar C, Speisky H. Double edge redox-implications for the interaction between endogenous thiols and copper ions: In vitro studies. Bioorg Med Chem 2008; 16(22):9795-9803
2008	Speisky H, Gómez M, Carrasco-Pozo C, Pastene E, Lopez-Alarcón C, Olea-Azar C. Cu(I)-Glutathione complex: a potential source of superoxide radicals generation. Bioorg Med Chem 2008; 16(13):6568-6574
2008	Henríquez C, Escobar B, Figuerola F, Chiffelle I, Speisky H, Estévez AM. Characterization of piñon seed (Araucaria araucana (Mol) K. Koch) and the isolated starch from the seed. Food Chem 2008; 107(2):592-601
2008	Speisky H, Peña A, Gómez M, Fredes C, Hurtado M, Gotteland M, Brunser O. Antioxidants in chilean berries. Acta Hort 2008; 777:485-492
2007	Muñoz O, Copaja S, Speisky H, Peña R, Montenegro G. Content of flavonoids and phenolic compounds in chilean honeys. Orac index. Quim Nova 2007; 30(4):848-851
2006	Carrasco-Pozo C, Alvarez-Lueje A, Olea-Azar C, López-Alarcón C, Speisky H. In vitro interaction between homocysteine and copper ions: Potential redox implications. Exp Biol Med 2006; 231(9):1569-1575
2006	Fellenberg MA, Speisky H. Antioxidants: Their effects on broiler oxidative stress and its meat oxidative stability. World’s Poultry Sci J 2006; 62(1):53-70
2006	O'Brien P, Carrasco-Pozo C, Speisky H. Boldine and its antioxidant or health-promoting properties. Chem Biol Interact 2006;159(1):1-17
2006	Speisky H, Rocco C, Carrasco C, Lissi EA, Lopez-Alarcon C. Antioxidant screening of medicinal herbal teas. Phytother Res 2006; 20(6):462-467
2005	Lopez-Alarcon C, Rocco C, Lissi E, Carrasco C, Squella JA, Nuñez-Vergara L, Speisky H. Reaction of 5-aminosalicylic Acid with peroxyl radicals: protection and recovery by ascorbic Acid and amino acids. Pharm Res 2005; 22(10):1642-1648
2005	Letelier ME, Pimentel A, Pino P, Lepe AM, Faundez M, Aracena P, Speisky H. Microsomal UDP-glucuronyltransferase in rat liver: oxidative activation. Basic Clin Pharmacol Toxicol 2005; 96(6):480-486
2005	Letelier ME, Lepe AM, Faundez M, Salazar J, Marin R, Aracena P, Speisky H. Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity. Chem Biol Interact 2005; 151(2):71-82
2004	Santanam N, Penumetcha M, Speisky H, Parthasarathy S. A novel alkaloid antioxidant, Boldine and synthetic antioxidant, reduced form of RU 486, inhibit the oxidation of LDL in vitro and atherosclerosis in vivo in LDLR (-/-) mice. Atherosclerosis 2004; 173(2):203-210
2004	López-Alarcón C, Speisky H, Squella JA, Olea-Azar C, Camargo C, Núñez-Vergara LJ. Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite. Pharm Res 2004; 21(10):1750-1757
2004	Núñez MT, Gallardo V, Muñoz P, Tapia V, Esparza A, Salazar J, Speisky H. Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells. Free Radic Biol Med 2004; 37(7):953-960
2003	Speisky H, Navarro P, Cherian MG, Jimenez I. Copper-binding proteins in human erythrocytes: searching for potential biomarkers of copper over exposure. Biometals 2003; 16(1):113-123
2003	Araya M, Olivares M, Pizarro F, Gonzalez M, Speisky H, Uauy R. Copper exposure and potential biomarkers of copper metabolism. Biometals 2003; 16(1):199-204
2003	Loghin F, Chagraoui L, Asencio M, Comoy E, Speisky H, Cassels BK, Protais P. Effect of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice. Eur J Pharm Sci 2003; 18(2):133-140
2003	Araya M, Olivares M, Pizarro F, Gonzalez M, Speisky H, Uauy R. Gastrointestinal symptoms and blood indicators of copper load in apparently healthy adults undergoing controlled copper exposure. Am J Clin Nutr 2003; 77:646-650
2002	Jimenez I, Aracena P, Letelier ME, Navarro P, Speisky H. Chronic exposure of HepG2 cells to excess copper results in depletion of glutathione and induction of metallothionein. Toxicology in Vitro 2002; 16:167-175
2000	Jimenez I, Garrido A, Bannach R, Gotteland M, Speisky H. Protective effect of boldine against free radical-induced erythrocyte lysis. Phytother Res 2000; 14:339-343
2000	Jimenez I, Speisky H. Effects of copper ions on the free radical-scavenging properties of reduced glutathione: implications of a complex formation. Trace Elem Med Biol 2000; 14(3):161-167
2000	Jimenez I, Speisky H. Biological disposition of boldine: in vitro and in vivo studies. Phytother Res 2000; 14(4):254-260
2000	Jimenez I, Lissi E, Speisky H. Free-radical-induced inactivation of lysozyme and carbonyl residue generation in the protein are not necessarily associated. Arch Biochem Biophys 2000; 381(2):247-252
1999	Asencio M, Delaquerriere B, Cassels B, Speisky H, Comoy E, Protais P. Biochemical and behavioral effects of boldine and glaucine on dopamine systems. Pharmacol Biochem Behav 1999; 62:7-13
1998	Mendez E, Sanhueza J, Nieto S, Speisky H, Valenzuela A. Fatty acid composition, extraction, fractionation, and stabilization of bullfrog (rana catesbeiana) oil. JAOCS 1998; 75:67-71
1998	Ganga A, Nieto S, Sanhueza J, Romo C, Speisky H, Valenzuela A. Concentration and stabilization of n-3 polyunsaturated fatty acids from sardine oil. JAOCS 1998; 75:733-736
1998	Olivares M, Pizarro F, Speisky H, Lönnerdal B, Uauy R. Copper in infant nutrition: safety of WHO provisional guideline value for copper content of drinking water. J Pediatr Gastroenterol Nutr 1998; 26:251-257
1998	Hidalgo ME, Gonzalez I, Toro F, Fernandez E, Jimenez I, Speisky H. Boldine as a sunscreen: its photoprotector capacity against UVB radiation. Cosmet Toiletries 1998; 113: 59-66
1997	Mendez E, Sanhueza J, Speisky H, Valenzuela A. Comparison of two Rancimat evaluation modes in the assessment of the relative stability of fish oil. J Am Oil Chem Soc 1997; 74:331-332
1997	Jimenez I, Gotteland M, Zarzuelo A, Uauy R, Speisky H. Loss of the metal binding properties of metallothionein induced by hydrogen peroxide and free radicals. Toxicology 1997; 120:37-46
1997	Gotteland M, Jimenez I, Brunser O, Guzman L, Romero S, Cassels B, Speisky H. Protective effects of boldine in experimental colitis. Planta Med 1997; 63:311-315
1997	Mendez E, Sanhueza J, Speisky H, Valenzuela A. Comparison of rancimat evaluation modes to assess oxidative stability of fish oils. J Am Oil Chem Soc 1997; 74(3):331-332
1997	Aposhian V, Arroyo A, Cebrian M, Del Razo LM, Hurlbult KH, Dart RC, Gonzalez-Ramirez D, Kreppel H, Speisky H, Smith A, Gonsebatt ME, Ostrovsky-Wegman P, Aposhian MM. DMPS-arsenic challenge test: l-increased urinary excretion of monomethylarsonic acid in humans given dimercaptopropane sulphonate. J Pharmacol Exp Ther 1997; 282(1):192-200
1996	Bannach R, Valenzuela A, Cassels BK, Nuñez-Vergara L, Speisky H. Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes. Cell Biol Toxicol 1996; 12:89-100
1996	Luza S, Speisky H. Liver copper storage and transport during development: implications for citotoxicity. Am J Clin Nutr 1996; 63:812S-820S
1996	Mendez E, Sanhueza J, Speisky H, Valenzuela A. Validation of the Rancimat test for the assessment of the relative stability of fish oils. J Am Oil Chem Soc 1996; 73:1033-1037
1995	Cassels B, Asencio M, Conget P, Speisky H, Videla L, Lissi E. Structure-antioxidative activity relationships in benzylisoquinoline alkaloids. Pharmacol Res 1995; 31:103-107
1995	Hu J, Speisky H, Cotgreave IA. The inhibitory effects of boldine, glaucine and probucol on TPA-induced down regulation of gap junction function: Relationships to intracellular peroxides, protein kinase C, translocation and connexin 43 phospholiration. Biochem Pharmacol 1995; 50(10):1635-1643
1994	Speisky H, Cassels B. Boldo and boldine: An emerging case of natural drug development. Pharmacol Res 1994; 29(1):1-12
1994	Morello A, Lipchenca J, Cassels B, Speisky H, Aldunate J, Repetto Y. Trypanocidal effect of boldine and related alkalids upon several strains of trypanosoma Cruzi. Comp Biochem Physiol 1994; 107C(3):367-371
1994	Gonzalez-Cabello R, Speisky H, Bannach R, Valenzuela A, Feher J, Gergely P. Effects of boldine on cellular immune functions in vitro. J Invest Allergol Clin Immunol 1994; 4(3):139-145
1994	Hirai M, Iwamura S, Varghese G, Speisky H, Israel Y. Reciprocal gamma-glutamyl transferase and cystathionase activity in guinea pig, rat and human liver. J Hepatol 1994; 21:683-688
1994	Backhouse N, Del Porte C, Givemau M, Cassels BK, Valenzuela A, Speisky H. Anti-inflammatory and anti-pyretic effects of boldine. Agents Actions 1994; 42:114-117
1993	Speisky H, Valenzuela A, Nieto S, Cassels B, Nuñez-Vergara L. Determination of boldine in plasma by high performance liquid chromatography. J Chromatogr 1993; 612(2):315-319
1993	Asencio M, Cassels B, Speisky H, Valenzuela A. (R)-and (S)-Coclaurine from the bark of Peumos boldus. Fitoterapia 1993; 64(5):455-458
1992	Speisky H. Age-dependent removal of circulating glutathione by the perfused rat liver: Role of gamma-glutamyl transferase. Age 1992; 15:104-107
1992	Shackel NA, Speisky H, Wade DN. Hepatic glutathione degradation within the sinusoids of guinea pig livers shows a periportal localization of gamma glutamyl-transferase activity. Agents Actions 1992; 36(3-4):289-294
1992	Cederbaum AI, Kukielka E, Speisky H. Inhibition of rat liver microsomal lipid peroxidation by boldine. Biochem Pharmacol 1992; 44(9):1765-1772
1991	Nuñez-Vergara L, Yudelevich J, Squella A, Speisky H. Drug-acetaldehyde interactions during ethanol metabolism in vitro. Alcohol Alcohol 1991; 26:139-144
1991	Speisky H, Cassels B, Lissi E, Videla L. Antioxidant properties of the alkaloid boldine in systems undergoing lipid peroxidation and enzyme inactivation. Biochem Pharmacol 1991; 41:1575-1581
1991	Cameron R, Armstrong D, Gunasekara A, Varghese G, Speisky H. Utilization of circulating GSH by nodular and cancerous intact rat liver. Carcinogenesis 1991; 12:2369-2372
1991	Speisky H, Squella A, Nuñez-Vergara L. Activity of boldine on rat ileum. Planta Medica 1991; 57(6):519-522
1991	Valenzuela A, Nieto S, Cassels B, Speisky H. Inhibitory effect of boldine on fish oil oxidation. J Am Oil Chem Soc 1991; 68(12):935-937
1990	Speisky H, Israel Y. Gamma-glutamyl transferase ectoactivity in the intact rat liver: effect of chronic alcohol consumption. Alcohol 1990; 7(4):339-347
1990	Speisky H, Shackel N, Varghese G, Wade D, Israel Y. Role of hepatic gamma-glutamyltransferase in the degradation of circulating glutathione: studies in the intact guinea pig perfused liver. Hepatology 1990; 11(5):843-849
1990	Turner CJ, Bhatnagar MK, Speisky H. Effect of subchronic administration of ethanol and methylmercury in combination on the tissue distribution of mercury in rats. Can J Physiol Pharmacol 1990; 68(12):1558-1562.
1989	Lindros KO, Penttilä KE, Gaasbeek Janzen JW, Moorman AF, Speisky H, Israel Y. The gamma-glutamyltransferase/glutamine synthetase activity ratio. A powerful marker for the acinar origin of hepatocytes. J Hepatol 1989; 8(3):338-343
1988	Speisky H, Kera Y, Penttilä KE, Israel Y, Lindros KO. Depletion of hepatic glutathione by ethanol occurs independently of ethanol metabolism. Alcohol Clin Exp Res 1988; 12(2):224-228
1987	Kera Y, Speisky H, Penttilä KE, Sippel H, Lindros KO. Glutathione metabolism in isolated rat hepatocytes: acinar heterogeneity of detoxifying enzymes and effects of ethanol. Alcohol Alcohol 1987; 1 Suppl:235-239
1987	Speisky H, Gunasekara A, Varghese G, Israel Y. Basolateral gamma-glutamyl transferase ectoactivity in rat liver: effects of chronic alcohol consumption. Alcohol Alcohol 1987; 1 Suppl:245-249
1985	Speisky H, MacDonald A, Giles G, Orrego H, Israel Y. Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration. Turnover studies. Biochem J 1985; 225(3):565-572
1985	Speisky H, Bunout D, Orrego H, Giles HG, Gunasekara A, Israel Y. Lack of changes in diene conjugate levels following ethanol induced glutathione depletion or hepatic necrosis. Res Comm Chem Pathol Pharmacol 1985; 48(1):77-90

Revistas Nacionales
2007	López-Alarcón C, Speisky H, Lissi E. Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation. Biol Res 2007; 40(2):155-162
2000	Speisky H, Jimenez I. Radicales libres y antioxidantes en la prevención de enfermedades(I): Mecanismos de generación de radicales libres (Free radicals and antioxidants in disease prevention: (I) Free radical-generating mechanisms). Rev Chil Nutr 2000; 27(1):48-55
2000	Jimenez I, Speisky H. Radicales libres y antioxidantes en la prevención de enfermedades (II): Mecanismos de defensa antioxidante (Free radicals and antioxidants in disease prevention: (II) antioxidant defense mechanisms). Rev Chil Nutr 2000; 27(2):210-219
2000	Speisky H, Jimenez I. Radicales libres y antioxidantes en la prevención de enfermedades (III): Evidencias clínico-epidemiológicas de los riesgos y beneficios asociados al consumo de antioxidantes en la prevención de enfermedades cardiovasculares (Free radicals and antioxidants in disease prevention (III): clinical and epidemiological evidences of the risks and benefits associated with antioxidant consumption in cardiovascular diseases prevention). Rev Chil Nutr 2000; 27(3):314-325
1995	Gotteland M, Espinoza J, Cassels B, Speisky H. Efecto de un extracto seco de boldo sobre el tránsito intestinal en voluntarios sanos (Effect of a dry boldo extract on oro cecal intestinal transit time in healthy volunteers). Rev Med Chil 1995; 123:955-960
1995	Speisky H, Squella JA, Nuñez-Vergara LJ. Implicancias farmacocinéticas asociadas al uso de fármacos como racematos o enantiómeros puros (Pharmacokinetic implications associated to the use of drugs as racemates or pure). Rev Med Chil 1995; 123:884-891
1993	Asencio M, Cassels B, Speisky H. The methylation of boldine with diazomethane. Bol Soc Chil Quim 1993; 38:331-334
1993	Asencio M, Cassels B, Speisky H. The methylation of boldine with diazomethane. Bol Soc Chil Quím 1993; 38:331-334

Capítulos en Libros
2008	Speisky H. Frutas y verduras como fuentes de antioxidantes naturales: Su importancia para la salud humana (Fruits and vegetables as sources of natural antioxidants: Its role for human health). En:Chile. Ministerio de Agricultura; Universidad de Chile, INTA; Corporación 5 al Día. Contribución de la política agraria al consumo de frutas y verduras en Chile: Un compromiso con la nutrición y la salud de la población. Santiago: Maval Ltda., 2008. p.45-60
1992	Israel Y, Speisky H, Lanca AJ, Iwamura S, Hirai M, Varghese G. Metabolism of hepatic glutathione and its relevance in alcohol induced liver damage. In: Clement B, Guillouzo A., editors. Cellular and molecular aspects of cirrhosis.Paris: INSERM; 1992. p.25-37 (Colloque INSERM; 216)

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