Académicos y Profesionales

Alejandro Hernandez Kunstmann
Cirujano Dentista
Profesor Titular
Dolor crónico y analgesia; Malnutrición y desarrollo cerebral


Revistas Internacionales
2010
Perez H, Soto-Moyano R, Ruiz S, Hernandez A, Sierralta W, Olivares R, Núñez H, Flores O, Morgan C, Valladares L, Gatica A, Flores FJ.
A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat.
Neurosci Lett. 2010 Aug 3. [Epub ahead of print]PMID: 20674672
2010
Flores O, Núñez H, Perez H, Morgan C, Soto-Moyano R, Valladares L, Burgos H, Olivares R, Hernandez A.
beta-Adrenoceptor blockade depresses molecular and functional plasticities in the rat neocortex.
Brain Res Bull. 2010 Jul 30;82(5-6):284-8. Epub 2010 May 25.
2008
Hernandez A, Burgos H, Mondaca M, Barra R, Núñez H, Perez H, Soto Moyano R, Sierralta W, Fernández V, Olivares R, Valladares L.
Effect of prenatal protein malnutrition on long-term potentiation and BDNF protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization.
Neural Plast 2008; ID 646919 (9 p.)
2007
Arriagada O, Constandil L, Hernandez A, Barra R, Soto Moyano R, Laurido C.
Effects of interleukin-1beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats.
Int J Neurosci 2007; 117(5):617-625
2007
Infante C, Díaz M, Hernandez A, Constandil L, Pelissier T.
Expression of nitric oxide synthase isoforms in the dorsal horn of monoarthritic rats: effects of competitive and uncompetitive N-methyl-D-aspartate antagonists.
Arthritis Res Ther 2007; 9(3):R53-R60
2006
Sierralta W, Hernandez A, Valladares L, Perez H, Mondaca M, Soto-Moyano R.
Mild prenatal protein malnutrition increases alpha(2C)-adrenoceptor expression in the rat cerebral cortex during postnatal life.
Brain Res Bull 2006; 69(5):580-586
2006
Perez H, Ruiz S, Nuñez H, White A, Gotteland M, Hernandez A.
Paraventricular-coerulear interactions: role in hypertension induced by prenatal undernutrition in the rat.
Eur J Neurosci 2006; 24:1209-1219
2006
Soto Moyano R, Burgos H, Flores F, Valladares L, Ssierralta W, Fernández V, Perez H, Hernández P, Hernandez A.
Melatonin administration impairs visuo-spatial performance and inhibits neocortical long-term potentiation in rats.
Pharmacol Biochem Behav 2006; 85:408-414
2005
Soto Moyano R, Valladares L, Sierralta W, Perez H, Mondaca M, Fernandez V, Burgos H, Hernandez A.
Mild prenatal protein malnutrition increases alpha2C-adrenoceptor density in the cerebral cortex during postnatal life and impairs neocortical long-term potentiation and visuo-spatial performance in rats.
J Neurochem 2005; 93(5):1099-109
2004
Mondaca M, Hernandez A, Perez H, Valladares L, Sierralta W, Fernandez V, Soto Moyano R.
Alpha(2)-Adrenoceptor modulation of long-term potentiation elicited in vivo in rat occipital cortex.
Brain Res 2004; 1021(2):292-296
2004
Marchand F, Pelisier T, Edchalier A, Ardid D, Alloiu A, Soto Moyano R, Mondaca M, Laurido C, Constandil L, Hernandez A.
Blockade of supraspinal 5-HT1A receptors potentiates the inhibitory effect of venlafaxine on wind-up activity in mononeuropathic rats.
Brain Res 2004; 1008(2):288-292
2004
Mondaca M, Hernandez A, Valladares L, Sierralta W, Noseda R, Soto Moyano R.
Involvement of melatonin metabolites in the long-term inhibitory effect of the hormone on rat spinal nociceptive transmnission.
Pharmacol Biochem Behav 2004; 77(2):275-279
2004
Noseda R, Hernandez A, Valladares L, Mondaca M, Laurido c, Soto Moyano R.
Melatonin-induced inhibition of spinal cord synaptic potentiation in rats is MT(2) receptor-dependent.
Neurosci Lett 2004; 360(1-2):41-44
2004
Hernandez A, Constandil L, Laurido C, Pelissier T, Marchand F, Ardid D, Alloui A, Eschalier A, Soto Moyano R.
Venlafaxine-induced depression of wind-up activity in mononeuropathic rats is potentiated by inhibition of brain 5-HT1A receptor expression in vivo.
Int J Neurosci 2004; 114(2):229-242
2003
Laurido C, Hernandez A, Constandil L, Pelissier T.
Nitric oxide synthase and soluble guanylate cyclase are involved in spinal cord wind-up activity of monoarthritic, but not of normal rats.
Neurosci Lett 2003; 352(1):64-66
2003
Pelissier T, Laurido C, Kramer V, Hernandez A, Paeile C.
Antinociceptive interactions of ketamine with morphine or methadone in mononeuropathic rats.
Eur J Pharmacol 2003; 477(1):23-28
2003
Alvarez P, Saavedra G, Hernandez A, Paeile C, Pelissier T.
Synergistic antinociceptive effects of ketamine and morphine in the orofacial capsaicin test in the rat.
Anesthesiology 2003; 99(4):969-975
2003
Pelissier T, Alvarez P, Hernandez A.
Effect of long-term ketamine administration on vocalization to paw pressure and on spinal wind-up activity in monoarthritic rats.
Int J Neurosci 2003; 113(9):1305-1313
2003
Marchand F, Alloui A, Chapuy E, Jourdan D, Pelissier T, Ardid D, Hernandez A, Eschalier A.
Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats.
Pain 2003; 103(3):229-235
2003
Constandil L, Pelissier T, Soto Moyano R, Mondaca M, Saez H, Laurido C, Muñoz C, Lopez N, Hernandez A.
Interleukin-1B increases spinal cord wind-up activity in normal but not in monoarthritic rats.
Neurosci Lett 2003; 342:139-142
2002
Laurido C, Pelissier T, Soto Moyano R, Valladares L, Flores F, Hernandez A.
Effect of melatonin on at spinal cord nociceptive transmission.
Neuroreport 2002; 13:89-91
2001
Pelissier T, Hernandez A, Mestre C, Eschalier A, Laurido C, Paeile C, Alvarez P, Soto Moyano R.
Antinociceptive effect of clomipramine in monoarthritic rats as revealed by the paw pressure test and the C-fiber evoked reflex.
Eur J Pharmacol 2001; 416:51-57
2001
Hernandez A, Laurido C, Mondaca M, Pelissier T, Burgos H, Soto Moyano R.
Lesion of the bulbospinal noradrenergic pathways blocks desipramine-induced inhibition of the C-fiber evoked nociceptive reflex in rats.
Neurosci Lett 2001; 302:1-4
2001
Laurido C, Pelissier T, Perez H, Flores F, Hernandez A. Effect of ketamine on spinal cord nociceptive transmission in normal an monoarthritic rats. Neuroreport 2001; 12:1551-1554
1999
Soto Moyano R, Fernandez V, Sanhueza M, Belmar J, Kusch C, Perez H, Ruiz S, Hernandez A.
Effect of mild protein prenatal malnutrition and subsequent postnatal nutritional rehabilitation on noradrenaline release and neuronal density in the rat occipital cortex.
Dev Brain Res 1999; 116:51-58
1998
Perez H, Ruiz S, Laurido C, Hernandez A.
Locus coeruleus-mediated inhibition of chemosensory responses in the rat nucleus tractus solitarius is mediated by alpha 2 adrenoreceptors.
Neurosci Lett 1998; 249:37-40
1998
Soto Moyano R, Alarcon S, Belmar J, Kusch C, Perez H, Ruiz S, Hernandez A.
Prenatal protein restriction alters synaptic mechanisms of callosal connections in the rat visual cortex.
Int J Dev Neurosci 1998; 16:75-84
1998
Soto-Moyano R, Alarcon S, Hernandez A, Perez H, Ruiz S, Carreño P, Kusch C, Belmar J.
Prenatal malnutrition-induced functional alterations in callosal connections and in interhemispheric asymmetry in rats are prevented by reduction of noradrenaline synthesis during gestation.
J Nutr 1998 ; 128 : 1224-1231
1998
Soto Moyano R, Belmar J, Hernandez A.
Desnutrición precoz y neurotransmisores cerebrales.
Pediatrika 1998; 18:5-14
1997
Ruiz S, Fernandez V, Hernandez A, Perez H, Sanhueza-Tsutsumi M, Alarcon S, Soto Moyano R.
Enhancement of central noradrenaline release during development alters the packing density of neurons in the rat occipital cortex.
Biol Neonate 1997; 71:119-125
1996
Belmar J, Carreño P, Hernandez A, Soto Moyano R.
Malnutrition early in life impairs alpha-2 adrenoreceptor regulation of noradrenaline release in the rat cerebral cortex.
Nutr Res 1996; 16:1727-1734
1996
Laurido C, Hernandez A, Perez H.
Cross-tolerance to acute administration of mu and kappa opioid agonists at the spinal cord level in the rat.
Int J Neurosci 1996; 87:191-199
1995
Schlesinger L, Arevalo M, Simon V, Lopez M, Muñoz C, Hernandez A, Carreño P, Belmar J, White A, Haeffner Cavaillon N.
Immune depression induced by protein calorie malnutrition can be suppressed by lesioning central noradrenaline systems.
J Neuroimmunol 1995; 57:1-7
1995
Hernandez A, Soto Moyano R, Mestre C, Eschalier A, Pelissier T, Paeile C, Contreras E.
Intrathecal pertussis toxin but not cyclic AMP blocks kappa-opioid induced antinociception in rat.
Int J Neurosci 1995; 81:193-197
1994
Soto-Moyano R, Hernandez A, Perez H, Ruiz S, Carreño P, Alarcon S, Belmar J.
Clonidine treatment during gestation prevents functional deficits induced by prenatal malnutrition in the rat visual cortex.
Int J Neurosci 1994 ; 76 :237-248
1994
Schlesinger L, Muñoz C, Arevalo M, Lopez M, Simon V, Hernandez A, Carreño P, Belmar J.
Depressed immune response in malnourished rats correlates with increased thymic noradrenaline level.
Int J Neurosci 1994; 77:229-236
1993
Perez H, Hernandez A, Ruiz S, Paeile C, Soto Moyano R.
Long-term effects of neonatal capsaicin on C-fiber excitability and dorsal horn C-input processing in the rat.
Brain Res Bull 1993; 32:685-688
1993
Soto Moyano R, Hernandez A, Perez H, Ruiz S, Carreño P, Belmar J.
Functional alterations induced by prenatal malnutrition in callosal connections and interhemispheric asymmetry as revealed by transcallosal and visual evoked responses in the rat.
Exp Neurol 1993; 119:107-112
1993
Contreras E, Quijada L, Germany A, Fleckenstein R, Hernandez A.
Calcium channel antagonists and adenosine analogues decrease tolerance to opiate pentazocine and U-50488.
Gen Pharmacol 1993; 24:1203-1206
1993
Hernandez A, Contreras E, Paeile C, Perez H, Pelissier T, Quijada L, Soto Moyano R.
Calcium channel modulators modify K opioid-induced inhibition of C-fiber-evoked spinal reflexes in rat.
Int J Neurosci 1993; 72:167-174
1992
Cañas P, Hernandez A, Perez H.
Taurine induces bicuculline/strychnine-insensitive dose-dependent inhibition of cortical visual evoked responses.
Int J Neurosci 1992; 65:141-145
1992
Quijada L, Germany A, Hernandez A, Contreras E.
Effect of calcium channel antagonists and Bay K 8644 on the analgesic response to pentazocine and U 50488H.
Gen Pharmacol 1992; 23:837-842
1991
Soto-Moyano R, Hernandez A, Perez H, Ruiz S, Galleguillos X, Belmar J.
Yohimbine early in life alters functional properties of interhemispheric connections of rat visual cortex.
Brain Res Bull 1991 ; 26 : 259-263
1990
Perez H, Ruiz S, Hernandez A, Soto Moyano R.
Asymmetry of interhemispheric responses evoked in the prefrontal cortex of the rat.
J Neurosci Res 1990; 25:139-142
1990
Hernandez A, Paeile C, Perez H, Pelissier T, Soto Moyano R.
K-opioid receptor-mediated depression of activity evoked in convergent dorsal horn cells by thermal and nonthermal noxious stimulation.
Eur J Pharmacol 1990; 186:323-326
1989
Perez H, Hernandez A, Inostroza H.
Mu-opioid and kappa opioid modulation of olfactory bulb evoked potentials.
Int J Neurosci 1989; 49(3-4):329-332
1988
Soto Moyano R, Galvez J, Vallejos C, Hernandez A.
Topical application of morphine to the rat somatosensory cortex produces analgesia to tonic pain.
J Neurosci Res 1988; 19:511-514
1987
Perez H, Hernandez A, Almli CR.
Locus coeruleus stimulation modulates olfactory bulb evoked potentials.
Brain Res Bull 1987; 18:767-770
1987
Soto Moyano R, Hernandez A, Perez H, Ruiz S, Diaz-Veliz G, Belmar J.
Early malnutrition and changes in the induced release of noradrenaline in the profrontal cortex of adult rats.
Int J Neurosci 1987; 37:93-102
1987
Soto Moyano R, Ruiz S, Perez H, Hernandez A, Belmar J.
Early undernutrition and long-lasting functional derangement of the noradrenergic system projecting to the neocortex.
Nutr Rep Int 1987; 36:309-317
1986
Hernandez A, Soto Moyano R.
Effect of morphine-induced cortical excitation on spinal sensory transmission.
J Neurosci Res 1986;15:217-222
1986
Paredes H, Solis R, Palacios J, Rocha M, Montecinos AM, Ramos H, Hernandez A.
The use of intravenous lysine clonixinate for rapid pain relief: an open clinical study.
Curr Ther Res 1986; 40:86-91
1986
Ruiz S, Perez H, Hernandez A, Ramirez M, Fernandez M, Soto Moyano R.
Prefrontal cortex excitability in early postnatally malnourished rats.
Int J Neurosci 1986; 29:119-124
1985
Hernandez A, Neira S, Soto Moyano R.
Effect of morphine-induced cortical excitation on somatosensory responses evoked in the periaqueductal gray matter.
Eur J Pharmacol 1985; 115:305-308
1985
Hernandez A, Ruiz S, Perez H, Soto Moyano R.
Effect of early malnutrition on dynamics properties of axodendritic synapses in the rat prefrontal cortex.
J Neurobiol 1985; 16:389-393
1985
Perez H, Ruiz S, Hernandez A, Soto Moyano R.
Malnutrition-induced changes of responses evoked in the rat prefrontal cortex as revealed by sensitivity to strychnine.
Exp Neurol 1985; 90:684-688
1985
Ruiz S, Perez H, Hernandez A, Soto Moyano R.
Effect of early malnutrition on latencies of direct cortical responses evoked in the rat prefrontal cortex.
Nutr Rep Int 1985; 32:533-538
 
Revistas Nacionales
2002
Olivares R, Soto Moyano R, Hernandez A, Aboitiz F.
La malnutrición prenatal proteica leve afecta el desarrollo del cuerpo calloso anterior (Mild protein prenatal malnutrition specifically affects development of the anterior corpus callosum).
Rev Chil Anat 2002; 20(2):159-163
1997
Hernandez A, Laurido C, Mondaca M, Soto Moyano R.
Inhibición del reflejo nociceptivo C por desipramina: efecto de la denervación noradrenérgica a nivel espinal (Desipramine-induced inhibition of the nociceptive C reflex: effect of spinal cord noradrenergic denervation).
Contribuciones Científicas y Tecnológicas (USACH) 1997; 25(115):33-40
1995
Soto-Moyano R, Belmar J, Perez H, Ruiz S, Hernandez A.
Central noradrenaline hyperactivity early in life : a hypothesis on the origin of morpho-functional brain disorders induced by malnutrition.
Biol Res 1995 ; 28 : 105-111.
1988
Paredes H, Hernandez A, San Martin S, Arraztoa J.
Tratamiento farmacológico en tres pasos del dolor en cáncer. Experiencia preliminar en Chile (Three steps therapy of pain in patients with cancer. Preliminary experience in Chile).
Rev Med Chil 1988; 116:433-438
1986
Ruiz S, Perez H, Hernandez A, Fernandez M, Ramirez M, Soto Moyano R.
Efecto de la desnutrición prenatal sobre la excitabilidad de la corteza prefrontal de la rata (Effect of prenatal malnutrition on excitability of the rat prefrontal cortex).
Rev Chil Nutr 1986; 14(3):215-220
1985
Soto Moyano R, Perez H, Ruiz S, Hernandez A.
Efecto de la desnutrición precoz en áreas de la corteza cerebral relacionadas con aprendizaje y conducta. Estudios electrofisiológicos (Effect of early undernutrition on cerebral cortex areas related to learning and behavior. Electrophysiological studies).
Rev Chil Nutr 1985; 13(2):89-98
1982
Perez H, Ruiz S, Hernandez A, Soto Moyano R.
Acción de la desnutrición calórico-proteica en la reactividad cortical del área parietal asociativa de la rata (Effect of early protein-calorie undernutrition on cortical reactivity of the rat association area).
Rev Chil Nutr 1982; 10(3):213-230
 
Capítulos en Libros
1990
Hernandez A, Saavedra H.
Métodos no farmacológicos en el tratamiento del dolor (Non pharmacological methods in pain treatment).
En: Paeile C, Saavedra H., editores. El dolor: aspectos básicos y clínicos. Santiago: Editorial Mediterráneo; 1990. p.156-174
1989
Paredes H, Hernandez A.
Manjeo del dolor en cáncer (Management of cancer pain).
En: Arraztoa J, Orlandi L., editores. Avances en Oncología. Santiago: Editorial Mediterráneo; 1989. p.108-115 (Series Clínicas Sociedad Médica de Santiago); v.8, n.1)
1989
Soto Moyano R, Hernandez A, Perez H, Ruiz S, Belmar J.
Experimental studies on the effect of early malnutrition on the norepinephrinergic system projecting to the cerebral cortex.
In: Evrard P, Minkowski A., editors. Developmental neurobiology. New York; Raven Press; 1989. p.287-295 (Nestlé Nutrition Workshop Series; 12)