Magister en Ciencias Biológicas Doctor en Ciencias
Prof. Asociado
Regulación del transporte de metales trazas.
2012
Gaitán DA, Flores S, Pizarro F, Olivares M, Suazo M, Arredondo M. The effect of calcium on non-heme iron uptake, efflux, and transport in intestinal-like epithelial cells (Caco-2 cells). Biol Trace Elem Res 2012; 145(3):300-303
2012
Espinoza A, Le Blanc S, Olivares M, Pizarro F, Ruz M, Arredondo M. Iron, copper, and zinc transport: Inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA. Biol Trace Elem Res 2012; 146(2):281-286
2012
Araya M, Andrews M, Pizarro F, Arredondo M.
Chaperones CCS, ATOX and COXIV responses to copper supplementation in healthy adults.
Biometals 2012; 25(2):383-391
2012
Araya M, Núñez H, Pavez L, Arredondo M, Méndez M, Cisternas F, Pizarro F, Sierralta W, Uauy R, González M. Administration of high doses of copper to capuchin monkeys does not cause liver damage but induces transcriptional activation of hepatic proliferative responses. J Nutr 2012; 142(2):233-237
2012
Andrews M, Arredondo M.
Ferritin levels and hepcidin mRNA expression in peripheral mononuclear cells from anemic type 2 diabetic patients.
Biol Trace Elem Res 2012 Mar 18 (In Press)
2012
Andrews M, Arredondo M.
Hepatic and adipocyte cells respond differentially to iron overload, hypoxic and inflammatory challenge.
Biometals 2012 Apr 5 (In Press)
2012
Le Blanc S, Villarroel P, Candia V, Gavilán N, Soto N, Pérez-Bravo F, Arredondo M.
Type 2 diabetic patients and their offspring show altered parameters of iron status, oxidative stress and genes related to mitochondrial activity.
Biometals 2012 Mar 27 (In Press)
2012
Le Blanc S, Garrick MD, Arredondo M.
Heme Carrier Protein 1 (HCP1) transports heme and is involved in heme-Fe metabolism.
Am J Physiol Cell Physiol 2012 Apr 11 (In Press)
2011
Arredondo M, Espinoza A, Pizarro F, Araya M. Searching for specific responses to copper exposure: An in vitro copper challenge in peripheral mononuclear cells. Biol Trace Elem Res 2011; 142(3):407-414
2011
Gaitán D, Flores S, Saavedra P, Miranda C, Olivares M, Arredondo M, López de Romaña D, Lönnerdal B, Pizarro F. Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant women. J Nutr 2011; 141(9):1652-1656
2011
Mendiburo MJ, Le Blanc S, Espinoza A, Pizarro F, Arredondo M. Transepithelial heme-iron transport: effect of heme oxygenase overexpression. Eur J Nutr 2011; 50(5):363-371
2011
Arredondo M, Fuentes M, Jorquera D, Candia V, Carrasco E, Leiva E, Mujica V, Hertrampf E, Pérez Bravo F. Cross-talk between body iron stores and diabetes: Iron stores are associated with activity and microsatellite polymorphism of the heme oxygenase and type 2 diabetes. Biol Trace Elem Res 2011; 143(2):625-636
2011
Villarroel P, Flores S, Pizarro F, López de Romaña D, Arredondo M. Effect of dietary protein on heme iron uptake by Caco-2 cells. Eur J Nutr 2011; 50(8):637-643
2011
Leiva E, Mujica V, Brito K, Palomo I, Orrego R, Moore-Carrasco R, Vásquez M, Guzmán L, Nuñez S, Díaz N, Icaza G, Arredondo M. High levels of hsCRP are associated with carbohydrate metabolism disorder J Clin Lab Anal 2011; 25(6):375-381
2010
Arredondo M, Núñez H, López G, Pizarro F, Ayala M, Araya M.
Influence of estrogens on copper indicators: In vivo and in vitro studies.
Biol Trace Elem Res 2010; 134: 252-264
2009
Barbeito AG, Garringer HJ, Baraibar MA, Gao X, Arredondo M, Núñez MT, Smith MA, Ghetti B, Vidal R.
Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene.
J Neurochem 2009; 109(4):1067-1078
2008
Mujica V, Leiva E, Icaza G, Diaz N, Arredondo M,; Moore R, Orrego R, Vásquez M, Palomo I.
Evaluation of metabolic syndrome in adults of Talca City, Chile.
Nutr J 2008; 7:14 (20 p.)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397433/pdf/1475-2891-7-14.pdf
2008
Suazo M, Olivares F, Mendez MA, Pulgar R, Prohaska JR, Arredondo M, Pizarro F, Olivares M, Araya M, Gonzalez M.
CCS and SOD1 mRNA are reduced after copper supplementation in peripheral mononuclear cells of individuals with high serum ceruloplasmin concentration.
J Nutr Biochem 2008; 19(4):269-274
2008
Arredondo M, Kloosterman J, Núñez S, Segovia F, Candia V, Flores S, Le Blanc S, Olivares M, Pizarro F.
Heme Iron Uptake by Caco-2 Cells is a Saturable, Temperature Sensitive and Modulated by Extracellular pH and Potassium.
Biol Trace Elem Res 2008; 125(2):109-119
2008
Arredondo M, Gonzalez M, Olivares M, Pizarro F, Araya M.
Ceruloplasmin, an indicator of copper status.
Biol Trace Elem Res 2008; 123(1-3):261-269
2008
Núñez H, Araya M, Cisternas F, Arredondo M, Mendez M, Pizarro F, Ortiz A, Ortiz R, Olivares M.
Blood biochemical indicators in young and adult Cebus apella of both sexes.
J Med Primatol 2008; 37(1):12-17
2008
Ayala M, Pizarro F, Mendez MA, Arredondo M, Araya M.
Copper and liver function indicators vary depending on the female hormonal cycle and serum hormone binding globulin (SHBG) concentration in healthy women.
Biol Trace Elem Res 2008; 121(1):9-15
2008
Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, Arredondo M, Duyckaerts C, Sazdovitch V, Zhao L, Garrick LM, Nuñez MT, Garrick MD, Raisman-Vozari R, Hirsch EC.
Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease.
Proc Natl Acad Sci U S A 2008; 105(47):18578-18583
2007
Arredondo M, Jorquera D, Carrasco E, Albala C, Hertrampf E.
Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus.
Am J Clin Nutr 2007; 86(5):1347-1353
2007
Leiva E, Mujica V, Elematore I, Orrego R, Díaz G, Prieto M, Arredondo M.
Relationship between Apolipoprotein E polymorphism and nephropathy in type-2 diabetic patients.
Diabetes Res Clin Pract 2007; 78(2):196-201
2006
Arredondo M, Salvat V, Pizarro F, Olivares M.
Bioavailability of hydrogen-reduced iron fortified bread: effect of iron particle size.
Nutr Res 2006; 26:235-239
2006
Arredondo M, Tapia V, Rojas A, Aguirre P, Reyes F, Marzolo MP, Nuñez MT.
Apical distribution of HFE-beta2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells.
Biometals 2006; 19(4):379-388
2005
Leiva E, Mujica V, Orrego R, Prieto M, Arredondo M.
Apolipoprotein E polymorphism in type 2 diabetic patients of Talca, Chile.
Diabetes Res Clin Pract 2005; 68(3):244-249
2005
Aguirre P, Mena N, Tapia V, Arredondo M, Nuñez MT.
Iron homeostasis in neuronal cells: a role for IREG1.
BMC Neurosci 2005; 6(1):3
2005
Cisternas F, Tapia G, Arredondo M, Cartier-Ugarte D, Romanque P, Sierralta W, Vial M, Videla L, Araya M.
Early histological and functional effects of chronic copper exposure in rat liver.
Biometals 2005; 18(5):541-551
2005
Arredondo M, Nuñez MT.
Iron and copper metabolism.
Mol Aspects Med 2005; 26(4-5):313-327
2005
Muñoz C, Lopez M, Olivares M, Pizarro F, Arredondo M, Araya M.
Differential response of interleukin-2 production to chronic copper supplementation in healthy humans.
Eur Cytokine Netw 2005; 16(4):261-265
2005
Araya M, Kelleher SL, Arredondo M, Sierralta W, Vial MT, Uauy R, Lonnerdal B.
Effects of chronic copper exposure during early life in rhesus monkeys.
Am J Clin Nutr 2005; 81(5):1065-1071
2004
Mazariegos DI, Pizarro F, Olivares M, Nuñez MT, Arredondo M.
The mechanisms for regulating absorption of Fe bis-glycine chelate and Fe ascorbate in caco-2 cells are similar.
J Nutr 2004; 134:395-398
2004
Arredondo M, Cambiazo V, Tapia L, Nuñez MT, Uauy R, Gonzalez M.
Copper overload affects copper an iron metabolism in HepG2 cells.
Am J Physiol Gastrointest Liver Physiol 2004; 287(1):G27-32
2003
Pizarro F, Olivares M, Hertrampf E, Mazariegos DI, Arredondo M.
Heme-iron absorption is saturable by heme-iron dose in women.
J Nutr 2003; 133:2214-2217
2003
Pizarro F, Olivares M, Hertrampf E, Arredondo M.
Reply to O. Pineda: Iron bis-glycine chelate competes for the nonheme-iron absorption pathway.
Am J Clin Nutr 2003; 78:493-497 (Letter)
2003
Arredondo M, Muñoz P, Mura C, Nuñez MT.
DMT1, a physiologically relevant apical Cu+1 transporter of intestinal cells.
Am J Physiol Cell Physiol 2003; 284:C1525-C1530
2003
Nuñez MT, Nuñez C, Tapia V, Muñoz P, Mazariegos D, Arredondo M, Mura C, Maccioni R.
Iron-activated iron uptake: a positive feedback loop mediated by iron regulatory protein 1.
Biometals 2003; 16:83-90
2002
Pizarro F, Olivares M, Hertrampf E, Mazariegos DI, Arredondo M, Letelier A, Gidi V.
Iron bis-glycine chelate competes for the nonheme-iron absorption pathway.
Am J Clin Nutr 2002; 76(3):577-581
2001
Arredondo M, Muñoz P, Mura C, Nuñez M. HFE
inhibits apical iron uptake by intestinal epithelial (Caco-2) cells.
FASEB J 2001; 15(7):1276-1278
2000
Arredondo M, Uauy R, Gonzalez M.
Regulation of copper uptake and transport in intestinal cell monolayers by acute and chronic copper exposure.
Biochim Biophys Acta 2000; 1474:169-176
1999
Olivares M, Pizarro F, Walter T, Arredondo M, Hertrampf E.
Bioavailability of iron supplements consumed daily is not different from that of iron supplements consumed weekly.
Nutr Res 1999; 19(2):179-190
1997
Arredondo M, Orellana A, Garate M, Nuñez MT.
Intracellular iron regulates iron absorption and IRP activity in intestinal ephitelial (Caco-2) cells.
Am J Physiol 1997; 273:G275-G280
1996
Tapia V, Arredondo M, Nuñez MT.
The regulation of iron absorption by cultured instestinal epithelia (Caco-2) cell monolayers with varied Fe status.
Am J Physiol 1996; 271:G443-G447
1996
Nuñez MT, Tapia V, Arredondo M.
Intestinal epithelia cell (Caco-2) acquire iron through the basolateral endocytosis of transferrin.
J Nutr 1996; 126(9):2151-2158
1993
Walter T, Dallman PR, Pizarro F, Veloso L, Peña G, Bartholomey S, Hertrampf E, Olivares M, Letelier A, Arredondo M.
Effectiveness of iron-fortified infant cereal in prevention of iron deficiency anemia.
Pediatrics 1993; 91:976-982
2008
Valenzuela C, Letelier A, Olivares M, Arredondo M, Pizarro F.
Determinación de hierro, zinc y cobre en carne de bovino (Iron, zinc and copper content of cow meat).
Rev Chil Nutr 2008; 35(2):139-146
2006
Araya M, Pizarro F, Olivares M, Arredondo M, Gonzalez M, Mendez M.
Understanding copper homeostasis in humans and copper effects on health.
Biol Res 2006; 39(1):183-187
2006
Aguirre P, Mena N, Tapia V, Rojas A, Arredondo M, Núñez MT.
Antioxidant responses of cortex neurons to iron loading.
Biol Res 2006; 39(1):103-104
2006
Mendiburo MJ, Flores S, Pizarro F, Arredondo M.
Heme oxygenase 1 overexpression increases iron fluxes in caco-2 cells.
Biol Res 2006;39(1):195-197
2006
Arredondo M, Martinez R, Nuñez MT, Ruz M, Olivares M.
Inhibition of iron and copper uptake by iron, copper and zinc.
Biol Res 2006; 39(1):95-102
2006
Gaitan D, Olivares M, Arredondo M, Pizarro F.
Biodisponibilidad de hierro en humanos (Iron bioavailability in humans).
Rev Chil Nutr 2006; 33(2):142-148
2000
Olivares M, Pizarro F, Hertrampf E, Walter T, Arredondo M, Letelier A.
Fortificación de alimentos con hierro en Chile (Iron fortification of foods in Chile).
Rev Chil Nutr 2000; 27:340-344
2000
Nuñez M, Garate M, Arredondo M, Tapia V, Muñoz P.
The cellular mechanisms of body iron homeostasis.
Biol Res 2000; 33:133-142
1992
Arredondo M, Pizarro F, Walter T, Hertrampf E.
Determinación de ferritina sérica por ELISA (Serum ferritin assay by ELISA).
Rev Chil Nutr 1992; 20:43-50
1990
Arredondo M, Herrera G, Silva G, Muñoz M, Ziede J, Alfaro L.
Lípidos séricos en hipertensos y/o diabéticos de la ciudad de Antofagasta (Lipids in hypertension patients and/or diabetics from Antofagasta city).
Rev Chil Tecnol Med 1990; 13(2):650-654
1988
Arredondo M, Pizarro F, Walter T, Hertrampf E.
Determinación cuantitativa de hemoglobina fecal por fluorometría (Quantitative determination of fecal hemoglobin for fluorometrics).
Rev Chil Tecnol Med 1988; 11:549-554
1985
Silva G, Acuña O, Arredondo M, Vega R, Muñoz M.
Efecto crónico de Li en la presión arterial de rata (Lithium chronic effect in rat arterial pressure).
Rev Chil Tecnol Med 1985; 8(1):319-324
1984
Arredondo M, Alfaro L, Silva G, Mamani T.
Determinación de calicreína urinaria (C.U.) por método indirecto en mamíferos (Urinary kallikrein determination by indirect method in mammals).
Rev Chil Tecnol Med 1984; 71(1-2):249-255
2010
Olivares M, Arredondo M, Pizarro F. Hierro (Iron). En: Gil A., editor. Tratado de nutrición. 2ª ed. Madrid:
Editorial Médica Panamericana; 2010. v. 1, p. 668-686
2005
Olivares M, Castillo Duran C, Arredondo M, Uauy R. Cobre y zinc en nutrición humana (Copper and zinc in human nutrition). En: Gil A., editor. Tratado de nutrición. Madrid: Acción Médica; 2005. vol.1, p.973-996
2005
Palomo I, Olivares M, Arredondo M, Pizarro F.
Alteraciones del metabolismo del hierro y de la síntesis del Hem (Alterations of iron metabolism and hem synthesis).
En: Palomo I, Pereira J, Palma J., editores. Hematología: Fisiopatología y diagnóstico. Talca: Universidad de Talca; 2005. p. 133-159
2005
Palomo I, Pizarro F, Olivares M, Arredondo M, Alarcón M, Pombo G.
Estudio de laboratorio de anemias nutricionales (Laboratory study of nutritional anemias).
En: Palomo I, Pereira J, Palma J., editores. Hematología: Fisiopatología y diagnóstico. Talca: Universidad de Talca; 2005. p.691-700
1990
Walter T, Hertrampf E, Arredondo M, Vega V.
Gastrointestinal iron losses in infancy: effect of the diet.
In: Hercberg S, Galan P, DupinH., editors. Recent knowledge on iron and folate deficiencies in the world. Paris: INSERM; 1990. p. 283-290 (Colloque INSERM; v.197)