Licenciado en Biología Ph D en Biología Celular y Molecular, Pontificia Universidad Católica
Prof. Asociado
Metabolismo celular de metales traza
2012
Hödar C, Moreno P, di Genova A, Latorre M, Reyes-Jara A, Maass A, González M, Cambiazo V. Genome wide identification of Acidithiobacillus ferrooxidans (ATCC 23270) transcription factors and comparative analysis of ArsR and MerR metal regulators. Biometals 2012; 25(1):75-93
2012
Araya M, Núñez H, Pavez L, Arredondo M, Méndez M, Cisternas F, Pizarro F, Sierralta W, Uauy R, González M. Administration of high doses of copper to capuchin monkeys does not cause liver damage but induces transcriptional activation of hepatic proliferative responses. J Nutr 2012; 142(2):233-237
2012
López G, Latorre M, Reyes-Jara A, Cambiazo V, González M.
Transcriptomic response of Enterococcus faecalis to iron excess.
Biometals 2012 Mar 24 (In Press)
2011
Latorre M, Olivares F, Reyes-Jara A, López G, González M. CutC is induced late during copper exposure and can modify intracellular copper content in Enterococcus faecalis. Biochem Biophys Res Commun 2011; 406(4):633-637
2011
di Genova A, Aravena A, Zapata L, González M, Maass A, Iturra P. SalmonDB: A bioinformatics resource for Salmo salar and Oncorhynchus mykiss. Database (Oxford) 2011 Nov 26; 2011: bar 050
2011
Vázquez MC, del Pozo T, Robledo FA, Carrasco G, Pavez L, Olivares F, González M, Zanlungo S. Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress. Plos One 2011; 6(12):e28777
2010
Del Pozo T, Cambiazo V, González M. Gene expression profiling analysis of copper homeostasis in Arabidopsis thaliana. Biochem BiophysiRes Comm 2010; 393(2):248-252
2010
Reyes-Jara A, Latorre M, López G, Bourgogne A, Murray BE, Cambiazo V, González M. Genome-wide transcriptome analysis of the adaptive response of Enterococcus faecalis to copper exposure. Biometals 2010; 23(6):1105-1112
2010
Nilo R, Saffie C, Lilley K, Baeza-Yates R, Cambiazo V, Campos-Vargas R, González M, Meisel LA, Retamales J, Silva H, Orellana A. Proteomic analysis of peach fruit mesocarp softening and chilling injury using difference gel electrophoresis(DIGE). BMC Genomics 2010; 11:43
2010
Hödar C, Assar R, Colombres M, Aravena A, Pavez L, González M, Martínez S, Inestrosa NC, Maass A. Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. BMC Genomics 2010 Jun 1; 11:348
2009
Vizoso P, Meisel LA, Tittarelli A, Latorre M, Saba J, Caroca R, Maldonado J, Cambiazo V, Campos-Vargas R, Gonzalez M, Orellana A, Silva H.
Comparative EST transcript profiling of peach fruits under different post-harvest conditions reveals candidate genes associated with peach fruit quality.
BMC Genomics 2009; 10(1):423
http://www.biomedcentral.com/content/pdf/1471-2164-10-423.pdf
2009
Zúñiga A, Hödar C, Hanna P, Ibáñez F, Moreno P, Pulgar R, Pastenes L, Gonzalez M, Cambiazo V.
Genes encoding novel secreted and transmembrane proteins are temporally and spatially regulated during Drosophila melanogaster embryogenesis.
BMC Biol 2009 Sep 22;7:61
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761875/pdf/1741-7007-7-61.pdf
2009
Suazo M, Hodar C, Morgan C, Cerpa W, Cambiazo V, Inestrosa NC, Gonzalez M. Overexpression of amyloid precursor protein increases copper content in HEK293 cells. Biochem Biophys Res Commun 2009; 382(4):740-744
2009
Arrázola MS, Varela-Nallar L, Colombres M, Toledo EM, Cruzat F, Pavez L, Assar R, Aravena A, González M, Montecino M, Maass M, Martínez S, Inestrosa NC. Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/β-catenin signaling pathway. J Cell Physiol 2009; 221:658-667
2008
Suazo M, Olivares F, Mendez MA, Pulgar R, Prohaska JR, Arredondo M, Pizarro F, Olivares M, Araya M, Gonzalez M.
CCS and SOD1 mRNA are reduced after copper supplementation in peripheral mononuclear cells of individuals with high serum ceruloplasmin concentration.
J Nutr Biochem 2008; 19(4):269-274
2008
González-Agüero M, Pavez L, Ibáñez F, Pacheco I, Campos-Vargas R, Meisel LA, Orellana A, Retamales J, Silva H, Gonzalez M, Cambiazo V.
Identification of woolliness response genes in peach fruit after post-harvest treatments.
J Exp Bot 2008; 59(8):1973-1986
2008
Arredondo M, Gonzalez M, Olivares M, Pizarro F, Araya M.
Ceruloplasmin, an indicator of copper status.
Biol Trace Elem Res 2008; 123(1-3):261-269
2008
Gonzalez M, Reyes A, Suazo M, Jo WJ, Vulpe C.
Expression of copper-related genes in response to copper load
Am J Clin Nutr 2008; 88:830S-834S
2006
Aracena J, Gonzalez M, Zuniga A, Mendez MA, Cambiazo V.
Regulatory network for cell shape changes during Drosophila ventral furrow formation.
J Theor Biol 2006; 239(1):49-62
2006
Latorre M, Silva H, Saba J, Guziolowski C, Vizoso P, Martinez V, Maldonado J, Morales A, Caroca R, Cambiazo V, Campos-Vargas R, Gonzalez M,
Orellana A, Retamales J, Meisel LA. JUICE: a data management system that facilitates the analysis of large volumes of information in an EST project workflow.
BMC Bioinformatics. 2006 Nov 23;7:513 (11 p.)
2005
Franco AM, Saldarriaga A, Martignon S, González MC, Villa AE.
Fluoride intake and fractional urinary fluoride excretion of Colombian preschool children.
Community Dent Health 2005; 22(4):272-278
2005
Franco AM, Martignon S, Saldarriaga A, González MC, Arbeláez MI, Ocampo A, Luna LM, Martínez-Mier EA, Villa AE.
Total fluoride intake in children aged 22-35 months in four Colombian cities.
Community Dent Oral Epidemiol 2005; 33(1):1-8
2005
Araya M, Olivares M, Pizarro F, Mendez MA, Gonzalez M, Uauy R.
Supplementing copper at the upper level of the adult dietary recommended intake induces detectable but transient changes in healthy adults.
J Nutr 2005; 135:2367-2371
2005
Gonzalez-Aguero M, Zuñiga A, Pottstock H, Del Pozo T, Gonzalez M, Cambiazo V.
Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization.
Gene 2005; 345(2):213-224
2004
Arredondo M, Cambiazo V, Tapia L, Nuñez MT, Uauy R, Gonzalez M.
Copper overload affects copper an iron metabolism in HepG2 cells.
Am J Physiol Gastrointest Liver Physiol 2004; 287(1):G27-32
2004
Tapia L, Gonzalez Aguero M, Cisternas MF, Suazo M, Cambiazo V, Uauy R, Gonzalez M.
Metallothionein is crucial for safe intracellular copper storage and cell survival at normal and supra-physiological exposure levels.
Biochem J 2004; 378(Pt 2):617-624
2004
Rodriguez JP, Gonzalez M, Rios S, Cambiazo V.
Cytoskeletal organization of human mesenchymal stem cells (MSC) changes during their osteogenic differentiation.
J Cell Biochem 2004; 93(4):721-731
2004
Mendez MA, Araya M, Olivares M, Pizarro F, Gonzalez M.
Sex and ceruloplasmin modulate the response to copper exposure in healthy individuals.
Environ Health Perspect 2004; 112(17):1654-1657
2003
Araya M, Olivares M, Pizarro F, Gonzalez M, Speisky H, Uauy R.
Copper exposure and potential biomarkers of copper metabolism.
Biometals 2003; 16(1):199-204
2003
Araya M, Olivares M, Pizarro F, Gonzalez M, Speisky H, Uauy R.
Gastrointestinal symptoms and blood indicators of copper load in apparently healthy adults undergoing controlled copper exposure.
Am J Clin Nutr 2003; 77:646-650
2003
Tapia L, Suazo M, Hödar C, Cambiazo V, Gonzalez M.
Copper exposure modifies the content and distribution of trace metals in mammalian cultured cells.
Biometals 2003; 16(1):169-174
2002
Rodriguez JP, Rios S, Gonzalez M.
Modulation of the proliferation and differentiation of human mesenchymal stem cells by copper.
J Cell Biochem 2002; 85(1):92-100
2002
Mendez MA, Hodar C, Vulpe C, Gonzalez M, Cambiazo V.
Discriminant analysis to evaluate clustering of gene expression data.
Febs Lett 2002; 522(1-3):24-28
2001
Cambiazo V, Gonzalez M, Maccioni RB.
Expression pattern of DMAP-85 during Drosophila embryonic development.
Mech Dev 2001; 108:197-201
2000
Arredondo M, Uauy R, Gonzalez M.
Regulation of copper uptake and transport in intestinal cell monolayers by acute and chronic copper exposure.
Biochim Biophys Acta 2000; 1474:169-176
1999
Cambiazo V, Gonzalez M, Isamit C, Maccioni RB.
The beta-isoform of heat shock protein Hsp-90 is structurally related with human microtubule-interacting protein Mip-90.
FEBS Lett 1999; 457:343-347
1999
Gonzalez MA, Castillo Duran C.
Talla materna y crecimiento del lactante nacido pretérmino (Maternal height and growth of Chilean premature infants).
Arch Latinoam Nutr 1999; 49:212-217
1999
Ruiz FH, Gonzalez M, Bodini M, Opazo C, Inestrosa NC.
Cysteine 144 is a key residue in the copper reduction by the Amyloid-?- precursor protein.
J Neurochem 1999; 73:1288-1292
1998
Gonzalez M, Cambiazo V, Maccioni RB.
The interaction of Mip-90 with microtubules and microfilaments in human fibroblasts.
Exp Cell Res 1998; 239:243-253
1998
Uauy R, Olivares M, Gonzalez M.
Essentiality of copper in humans.
Am J Clin Nutr 1998; 67(5 Suppl):952S-959S
1996
Gonzalez M, Garcia C, Nieto A.
Regional differences in uteroglobin biosynthesis along the rabbit oviduct: Inmuno-histochemical and biochemical studies.
Histochem J 1996; 28:209-215
1995
Gonzalez M, Cambiazo V, Maccioni RB.
Identification of a new microtubule-interacting protein Mip-90.
Eur J Cell Biol 1995; 67:158-169
1995
Cambiazo V, Gonzalez M, Maccioni RB.
DMAP-85: a Tau-like protein from Drosophila melanogaster larvae.
J Neurochem 1995; 64:1288-1297
1995
Vial C, Armas Portela R, Avila J, Gonzalez M, Maccioni RB.
A 205 kDa protein from non-neuronal cells in culture contains tubulin binding epitopes.
Mol Cell Biochem 1995; 144:109-116
1974
Sierralta W, Gonzalez M, Minguell J.
The effect of testosterone on rat bone marrow ribonucleic acid metabolism.
J Steroid Biochem 1974; 5:645-648
Arrázola MS, Varela-Nallar L, Colombres M, Toledo EM, Cruzat F, Pavez L, Assar R, Aravena A, González M, Montecino M, Maass M, Martínez S, Inestrosa NC. Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/β-catenin signaling pathway. J Cell Physiol 2009; 221:658-667
2006
Araya M, Pizarro F, Olivares M, Arredondo M, Gonzalez M, Mendez M.
Understanding copper homeostasis in humans and copper effects on health.
Biol Res 2006; 39(1):183-187
2006
Armendariz AD, Olivares F, Pulgar R, Loguinov A, Cambiazo V, Vulpe CD, Gonzalez M.
Gene expression profiling in wild-type and metallothionein mutant fibroblast cell lines.
Biol Res 2006;39(1):125-142
2006
Reyes A, Leiva A, Cambiazo V, Mendez MA, Gonzalez M.
Cop-like operon: structure and organization in species of the Lactobacillale order.
Biol Res 2006; 39(1):87-93
2005
Meisel L, Fonseca B, Gonzalez S, Baeza-Yates R, Cambiazo V, Campos R, Gonzalez M, Orellana A, Retamales J, Silva H.
A rapid and efficient method for purifying high quality total RNA from peaches (Prunus persica) for functional genomics analyses.
Biol Res 2005; 38(1):83-88
2004
Gonzalez Macarena, Lizana L, Molina F, Muñoz I, Rodriguez-Osiac L, Castillo Duran C.
Evaluación de procedimientos relacionados con la alimentación parenteral, en dos centros pediátricos de hospitales públicos de Santiago (Evaluation of procedures associated with parenteral feeding in 2 public paediatric hospital in Santiago).
Rev Chil Pediatr 2004; 75(2):173-176
2001
Gonzalez MA, Castillo Duran C.
Crecimiento postnatal inicial de lactantes prematuros nacidos en Chillán, de acuerdo a residencia urbana o rural (Postnatal growth of low birth weight infants born in Chillan, Chile, according with urban or rural residence).
Rev Chil pediatr 2001; 72:496-503
2003
Uauy R, Gonzalez M, Olivares M, Araya M. Copper and human health: Effects of deficit and excess. In: Lagos GE, Warner AEM, Sánchez M., editors. Copper 2003. Montreal: Canadian Institute of Mining, Metallurgy and Petroleum; 2003. v.1, p.7-31
2003
Araya M, Olivares M, Gonzalez M, Pizarro F, Uauy R.
Copper biomarkers for human health.
In: Lagos GE, Warner AEM, Sánchez M., editors. Copper 2003. Montreal: Canadian Institute of Mining, Metallurgy and Petroleum; 2003. v.2, p.441-446
2002
Araya M, Gonzalez M, Olivares M, Uauy R.
Biological effects of chronic copper exposure.
In: Massaro E., editor. Handbook of copper pharmacology and toxicology. Totowa, NJ: Humana Press, Inc.; 2002. p.385-396
1999
Olivares M, Uauy R, Icaza G, Gonzalez M.
Models to evaluate health risks derived from copper exposure /Intake in humans.
In: Leone A, Mercer J, editors. Copper transport and its disorders. New York: Kluwer Academic / Plenum Publisher; 1999. p. 17-28 (Advances in Experimental Medicine and Biology; v.448)
1997
Olivares M, Gonzalez M, Icaza G, Uauy R.
Mechanism of adaptation to copper deficit and excess in humans: basis to assess health risk.
In: Lagos GE, Badilla Ohlbaum R., editors. Advances in risk assessment of copper in the environment. Santiago: Universidad Católica de Chile /Centro de Investigación Minera Metalúrgica; 1997. p. 291-326