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  • Publicaciones Académicos
  •    Ph. D. en Fisiología y Fisiopatología de la Nutrición Humana
       Prof. Titular
       Métodos no invasores de exploración funcional del tubo digestivo. Microbiota intestinal y salud. Alimentos funcionales, prebióticos y probióticos. Alimentos fermentados y flora láctica.

Revistas Internacionales

2012 Carrasco-Pozo C, Mizgier ML, Speisky H, Gotteland M. Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. Chem Biol Interact 2012; 195(3):199-205

2011 Carrasco-Pozo C, Speisky H, Brunser O, Pastene E, Gotteland M. Apple Peel Polyphenols Protect against Gastrointestinal Mucosa Alterations Induced by Indomethacin in Rats. J Agric Food Chem. 2011; 59: 6459-6466.

2011 Carrasco-Pozo C, Gotteland M, Speisky H. Apple peel polyphenol extract protects against indomethacin-induced damage in Caco-2 cells by preventing mitochondrial complex I inhibition. J Agric Food Chem 2011; 59(2):11501-11508

2011 Dubos C, Vega N, Carvallo C, Navarrete P, Cerda C, Brunser O, Gotteland M. Identification of Lactobacillus spp. in colostrum from Chilean mothers. Arch Latinoam Nutr 2011; 61(1):66-68

2011 Brignardello J, Morales P, Díaz E, Brunser O, Gotteland M. Increase of plasma fatty acids without changes in n-6/n-3 PUFA ratio in asymptomatic obese subjects. Arch Latinoam Nutr 2011; 61(2):149-163

2010 Mangin I, Suau A, Gotteland M, Brunser O, Pochart P.
Amoxicillin treatment modifies the composition of Bifidobacterium species in infant intestinal microbiota.
Anaerobe 2010; 16: 433-438


2010 Brunser O, Cruchet S, Gotteland M.
Probiotics as a tool for the management of Helicobacter pylori.
US Gastroenterol Hepatol Rev 2010; 6: 22-26


2010 Brignardello J, Morales P, Diaz E, Romero J, Brunser O, Gotteland M. Pilot study: Alterations of intestinal microbiota in obese are not associated with colonic inflammation or disturbances of barrier function. Aliment Pharmacol Ther 2010; 32: 1307-1314

2010 Carrasco-Pozo C, Gotteland M, Speisky H. Protection by apple peel polyphenols against indomethacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 Cells. J Pharm Pharmacol 2010; 62: 943-950

2010 Cáceres P, Montes S, Vega N, Cruchet S, Brunser O, Gotteland M. Effects of Lactobacillus rhamnosus HN001 on acute respiratory infections and intestinal secretory IgA in children. J Pediatr Infect Dis 2010; 5: 353-362

2008 Speisky H, Peña A, Gómez M, Fredes C, Hurtado M, Gotteland M, Brunser O.
Antioxidants in chilean berries.
Acta Hort 2008; 777:485-492


2008 Haschke-Becher E, Brunser O, Cruchet S, Gotteland M, Haschke F, Bachmann C.
Urinary D-lactate excretion in infants receiving Lactobacillus johnsonii with formula.
Ann Nutr Metab 2008; 53(3-4):240-244


2008 Mao M, Yu T, Xiong Y, Wang Z, Liu H, Gotteland M, Brunser O.
Effect of a lactose-free milk formula supplemented with bifidobacteria and streptococci on the recovery from acute diarrhoea.
Asia Pac J Clin Nutr 2008; 17(1):30-34


2008 Gotteland M, Andrews M, Toledo M, Muñoz L, Caceres P, Anziani A, Wittig E, Speisky H, Salazar G.
Modulation of Helicobacter pylori colonization with cranberry juice and Lactobacillus johnsonii La1 in children.
Nutrition 2008; 24(5):421-426


2007 Olguín F, Rivera R, Brunser O, Olguín R, Gotteland M.
Estudio de la función de barrera gástrica e intestinal y su evolución en el tiempo en pacientes quemados (Study of gastric and intestinal barrier function and its temporal evolution in burn patients).
Cir Plast Iberolatinoam 2007; 33(4):203-208


2007 Perez H, Ruiz S, Núñez H, White A, Gotteland M.
Coerulear activation by CRH and its role in hypertension induced by prenatal malnutrition in the rat.
Int J Neurosc 2007; 117(5):627-642


2006 Mangin I, Suau A, Magne F, Garrido D, Gotteland M, Neut C, Pochart P.
Characterization of human intestinal bifidobacteria using competitive PCR and PCR-TTGE.
FEMS Microbiol Ecol 2006; 55:28-37


2006 Brunser O, Gotteland M, Cruchet S, Figueroa G, Garrido D, Steenhout P.
Effect of a milk formula with prebiotics on the intestinal microbiota of infants after an antibiotic treatment.
Pediatr Res 2006; 59:451-456


2006 Reyes H, Zapata R, Hernández I, Gotteland M, Sandoval L, Jirón MI, Palma J, Almuna R, Silva JJ.
Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?.
Hepatology 2006; 43(4):715-722


2006 Gotteland M, Brunser O, Cruchet S.
Systematic review: are probiotics useful in controlling gastric colonization by Helycobacter pylori?.
Aliment Pharmacol Ther 2006; 23:1077-1086


2006 Brunser O, Figueroa G, Gotteland M, Haschke-Becher E, Magliola C, Rochat F, Cruchet S, Palframan R, Gibson G, Chauffard F, Haschke F.
Effects of probiotic or prebiotic supplemented milk formulas on fecal microbiota composition of infants.
Asia Pac J Clin Nutr 2006; 15(3):368-376


2006 Perez H, Ruiz S, Nuñez H, White A, Gotteland M, Hernandez A.
Paraventricular-coerulear interactions: role in hypertension induced by prenatal undernutrition in the rat.
Eur J Neurosci 2006; 24:1209-1219


2005 Gotteland M, Poliak L, Cruchet S, Brunser O.
Effect of regular ingestion of Saccharomyces boulardii plus inulin or Lactobacillus acidophilus LB in children colonized by Helicobacter pylori.
Acta Paediatr 2005; 94:1747-1751


2005 Gotteland M, Cruchet S, Brunser O.
Can the amount of Helicobacter pylori in the stomach be kept low through probiotic intake?.
Am J Clin Nutr 2005; 81:939(Letter)


2005 Olguin F, Araya M, Hirsch S, Brunser O, Ayala V, Rivera R, Gotteland M.
Prebiotic ingestion does not improve gastrointestinal barrier function in burn patients.
Burns 2005; 31(4):482-488


2005 Garrido D, Suau A, Pochart P, Cruchet S, Gotteland M.
Modulation of the fecal microbiota by the intake of a Lactobacillus johnsonii La1-containing product in human volunteers.
FEMS Microbiol Lett 2005; 248(2):249-256


2004 De la Maza MP, Agudelo GM., Gotteland M, Yudin T, Gattás V, Barrera G, Bunout D, Hirsch S. Long-term nutritional and digestive consequences of pelvic radiation. J. Am Coll Nutr 2004;23;102-7.

2003 Gotteland M, Cruchet S.
Suppresive effect of frequent ingestion of Lactobacillus johnsonii LA1 on Helicobacter pylori colonization in asymptomatic volunteers.
J Antimicrob Chemother 2003: 51:1317-1319


2003 Cruchet S, Obregon MC, Salazar G, Diaz E, Gotteland M.
Effect of the ingestion of a dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children.
Nutrition 2003; 19(9):716-721


2002 Verbeke S, Gotteland M, Fernandez M, Bremer J, Rios G, Brunser O.
Basement membrane and connective tissue proteins in intestinal mucosa of patients with coeliac disease.
J Clin Pathol 2002; 55(6):440-445


2002 Gotteland M, Cruchet S, Frau V, Wegner ME, Lopez R, Herrera T, Sanchez A, Urrutia C, Brunser O.
Effect of cigarette smoking, alone or with alcohol, on gastric function in healthy volunteers.
Dig Liver Dis 2002; 34:702-706


2001 Gotteland M, Araya M, Olivares M, Pizarro F.
Effect of acute copper exposure on gastrointestinal permeabily in healthy volunteers.
Dig Dis Sci 2001; 46(9):1909-1914


2001 Gotteland M, Cruchet S, Verbeke S.
Effect of Lactobacillus ingestion on the gastrointestinal mucosal barrier alterations induced by indomethacin in humans.
Aliment Pharmacol Ther 2001; 15:11-17


2001 De la Maza MP, Gotteland M, Ramirez C, Araya M, Yudin T, Bunout D, Hirsch S.
Acute nutritional and intestinal changes after pelvic radiation.
J Am Coll Nutr 2001; 20:637-642


2001 Gotteland M, Corvalan A, Sarmiento F, Chavez E, Backhouse C, Palma M, Kakarieka E, Vial MT, Figueroa G.
Gastric permeability is not increased in children colonized by cagA-positive strains of Helicobacter pylori.
Dig Liver Dis 2001; 33:750-754


2000 Jimenez I, Garrido A, Bannach R, Gotteland M, Speisky H.
Protective effect of boldine against free radical-induced erythrocyte lysis.
Phytother Res 2000; 14:339-343


1999 Gotteland M, Lopez M, Muñoz C, Saez R, Altshiller H, Llorens P, Brunser O.
Local and systemic liberation of proinflammatory cytokines in ulcerative colitis.
Dig Dis Sci 1999; 44:830-835


1999 Hirsch S, De la Maza MP, Gattas V, Barrera G, Petermann M, Gotteland M, Muñoz C, Lopez M, Bunout D.
Nutritional support in alcoholic cirrhotic patients improves host defenses.
J Am Coll Nutr 1999; 18:434-441


1998 Gotteland M, Cruchet S, Araya M, Espinoza J, Brunser O.
Permeabilidad intestinal en el primer año de vida. Efecto de la diarrea (Intestinal permeability during the first year of life. Effect of diarrhoea).
An Esp Pediatr 1998; 49:125-128


1997 Jimenez I, Gotteland M, Zarzuelo A, Uauy R, Speisky H.
Loss of the metal binding properties of metallothionein induced by hydrogen peroxide and free radicals.
Toxicology 1997; 120:37-46


1997 Gotteland M, Jimenez I, Brunser O, Guzman L, Romero S, Cassels B, Speisky H.
Protective effects of boldine in experimental colitis.
Planta Med 1997; 63:311-315


1997 Vera JF, Gotteland M, Chavez E, Vial MT, Kakarieka E, Brunser O.
Sucrose permeability in children with gastric damage and Helicobacter infection.
J Pediatr Gastroenterol Nutr 1997; 24:506-511


1992 Gotteland M, Crain Denoyelle AM, Heyman M, Desjeux JF.
Effect of cow's milk proteins absorption on the anaphylactic and systemic immune responses of young rabbits during bacterial diarrhea.
Int Arch Allergy Appl Immunol 1992;97: 78-82


1992 Gotteland M, Pochart P, Dabbech M, Bisetti N, Desjeux JF.
In vivo effect of yogurt on excretion of enteropathogen Escherichia coli RDEC-1 during acute diarrhea in the just weaned rabbit.
J Pediatr Gastroenterol Nutr 1992; 14:264-267


1992 Nath SK, Dechelotte P, Darmaun D, Gotteland M, Rongier M, Desjeux JF.
15N and 14C glutamine fluxes across rabbit ileum in experimental bacterial diarrhea.
Am J Physiol 1992; 25:G312-G318


1990 Isaulori E, Gotteland M, Heyman M, Pochart P, Desjeux JF.
Antigen absorption in rabbit bacterial diarrhea (RDEC-1): in vitro modifications in the ileum and Peyer's patches.
Dig Dis Sci 1990; 35:360-366


1989 Gotteland M, Isaulori E, Heyman M, Tome D, Desjeux JF.
Antigen absorption in bacterial diarrhea: in vivo intestinal transport of ß-lactoglobulin in rabbits infected with the entero-adherent E.coli strain RDEC-1.
Pediatr Res 1989; 26:237-240


Revistas Nacionales

2011 Wiedeman A, Ochoa E, Maury E, Gotteland M. Utilización de suplementos nutricionales para el manejo del sobrepeso y obesidad: una revisión de la evidencia (Use of dietary supplements for the management of overweight and obesity: A review of the evidence). Rev Chil Nutr 2011; 38: 234-242

2010 Morales P, Brignardello J, Gotteland M. La microbiota intestinal: un nuevo actor en el desarrollo de la obesidad (The association of intestinal microbiota with obesity). Rev Med Chile 2010; 138: 1020-1027

2010 Gotteland M, Vizcarra M, Maury E. Efecto de un producto lácteo con probióticos y prebióticos sobre la función digestiva de sujetos sanos y constipados ((Effect of a milk product containing probiotics and prebiotics on the digestive function of healthy and constipated subjects). Rev Chil Nutr 2010; 37: 340-351

2010 Caceres P, Gotteland M. Alimentos probióticos en Chile ¿Qué cepas y qué propiedades? (Probiotics in Chile: which are the strains and what are their effects on human health?). Rev Chil Nutr 2010; 37: 97-109

2007 Gotteland M, De Pablo S.
Algunas verdades sobre el café (Some trues concerning coffee).
Rev Chil Nutr 2007; 34(2):105-115


2006 Gotteland M, Brunser O.
Efecto de un yogur con inulina sobre la función intestinal de sujetos sanos o constipados (Effect of inulin containing yogurt on intestinal function of healthy and constipated volunteers).
Rev Chil Nutr 2006; 33(3):553-560


2006 Gotteland M, Garrido D, Cruchet S.
Regulación de la microbiota intestinal en voluntarios sanos mediante el consumo de un producto con el probiótico Lactobacillus johnsonii La1 (Regulation of the intestinal microbiota of healthy volunteers through the intake of the probiotic Lactobacillus johnsonii La1).
Rev Chil Nutr 2006; 33(2):198-203


2004 Verbeke S, Cruchet S, Gotteland M, Ríos G, Hunter B, Chávez E, Brunser O, Araya M.
Tiempo de exposición al gluten y marcadores de riesgo de diabetes mellitus insulino dependiente en pacientes celíacos (Risk markers for insulin-dependent diabetes mellitus and duration of exposure to gluten in celiac patients).
Rev Med Chil 2004; 132(8):979-984


2004 Diaz E, Aguirre C, Gotteland M.
Efecto de un inhibidor de α-amylasa sobre la reducción de peso de mujeres obesas (Effect of an α-amylase inhibitor on body weight reduction in obese women).
Rev Chil Nutr 2004; 31(3):306-317


2003 Gotteland M, Verbeke S, Cruchet S, Brunser O, Rios G, Hunter B, Araya M.
Anticuerpos anti-transglutaminasa tisular: ¿Una mejor prueba para detectar transgresiones menores de la dieta en pacientes celíacos? (Tissue transglutaminase antibodies: a better test to detect minor dietary transgressions in celiac patients?).
Rev Med Chil 2003; 131(1):25-29


2003 Obregon MC, Cruchet S, Diaz E, Salazar G, Gotteland M.
El consumo regular de Lactobacillus Johnsonii LA1 interfiere con la colonización gástrica por Helicobacter pylori (Regular intake of Lactobacillus Johnsonii LA1 interferes with Helicobacter pylori colonizaction).
Rev Chil Nutr 2003; 30(3):243-249


2001 Gotteland M, Cruchet S, Brunser O.
Alimentos lácteos funcionales (Functional foods from milk).
Rev Chil Nutr 2001; 28(Supl 1):84-95


2001 Verbeke S, Gotteland M, Fernandez M, Brunser O.
Papel del tejido conectivo en la morfología y la función de la mucosa intestinal. Su importancia en la patogenia de la enfermedad celíaca ((Role of the connective tissue in the morphology and function of intestinal mucosa. Its participation in the pathogenesis of celiac disease).
Rev Med Chil 2001; 129:1333-1342


1999 Gotteland M.
Probióticos : microorganismos de la dieta al servicio de la salud (Probiotics: microorganisms of the diet working for health).
Rev Chil Nutr 1999; 26:20-34


1998 Chavez E, Sarmiento F, Lopez M, Kakarieka E, Vial MT, Gotteland M.
Niveles de interleuquina-8 en biopsias gástricas de niños colonizados por Helicobacter pylori (Gastric mucosal interleukin-8 in children colonized by Helicobacter pylori).
Rev Med Chil 1998; 126:139-143


1998 Gotteland M, Saenz R, Lopez M, Altshiller H, Llorens P, Brunser O.
Liberación de interleuquina-6 e interferon-g por células mononucleares de la sangre y de mucosa colónica de pacientes con colitis ulcerosa (IL-6 and IFN-g release by peripheral blood mononuclear cells and colonic lamina propria mononuclear cells from patients with ulcerative colitis).
Rev Med Chil 1998; 126:1043-1048


1998 Gotteland M, Brunser O.
Citoquinas e intestino. Implicaciones en las patologías crónicas del intestino (Intestinal cytokines. Implication in inflammatory bowel diseases).
Gastroenterol Latinoam 1998; 9:171-184


1997 Sarmiento F, Chavez E, Pizarro B, Kakarieka E, Vial MT, Gotteland M.
Infección por Helicobacter pylori y daño gástrico en niños de nivel socioeconómico bajo (Helicobacter pylori infection and gastric dammage in children of low socioeconomical status).
Rev Chil Pediatr 1997; 68:251-255


1997 Hirsch S, Chavez G, Gotteland M, De la Maza MP, Petermann M, Barrera P, Bunout D.
Permeabilidad intestinal en alcohólicos sin daño hepático (Intestinal permeability in alcoholic patients without liver damage).
Rev Med Chil 1997; 125:653-58


1995 Gotteland M, Espinoza J, Brunser O.
Uso clínico de las pruebas de permeabilidad en la exploración funcional del tubo digestivo (Clinical use of the permeability tests in the functional exploration of the gut).
Gastroenterol Latinoam 1995; 6:6-16


1995 Gotteland M, Espinoza J, Cassels B, Speisky H.
Efecto de un extracto seco de boldo sobre el tránsito intestinal en voluntarios sanos (Effect of a dry boldo extract on oro cecal intestinal transit time in healthy volunteers).
Rev Med Chil 1995; 123:955-960


Publicaciones

Libros

Capítulos de Libros

2010 Gotteland M, Cruchet S, Brunser O. Functional food in child nutrition. In: Smith J, Charter E., editors. Functional food product development. Oxford: Wiley-Blackwell; 2010, p. 440-458

2010 Brunser O, Gotteland M. Prebiotics and probiotics in human health: An overview. In: Watson R , Preedy V., editors. Bioactive foods in health promotion: Probiotics and prebiotic. Kidlington, UK: Academic Press; 2010, p. 73-93

2007 Brunser O, Gotteland M, Cruchet S.
Functional fermented milk products.
In: Agostoni C, Brunser O., editors. Issues in complementary feeding. Basel: Nestec Ltd., Vevey/S. Karger; 2007 (Nestlé Nutrition Workshop Series Pediatric Program; vol. 60). p. 235-250


2003 Araya M, Gotteland M.
Enfermedad celíaca (Celiac disease).
En: Velasco Benítez CA., editor. Enfermedades digestivas en niños. Cali: Feriva; 2003. p.63-70


2003 Gotteland M.
Fisiología intestinal - Digestión, absorción y secreción. (GastroIntestinal physiology - Digestion, absorption and secretion).
En: Rojas S, Sarmiento F., editores. Pediatria: diagnóstico y tratamiento. Bogotá: Celsus; 2003. p.825-832


2001 Gotteland M.
¿Cómo explorar el tubo digestivo con métodos no invasores? (How to explore the gut with non invasive methods?).
En : Meneghello J, Fanta E, Grau Martinez A, Blanco O., editores. Pediatría práctica en diálogos. Buenos Aires: Editorial Médica Panamericana; 2001. p.801-804


Informes Internacionales

2000 Brunser O, Cruchet S, Gotteland M, Verbeke S.
Treatment of children with H. pylori infection with probiotics: comparison with conventional methods. Research project on isotopic techniques to examine the significance of infection and other insults in early childhood to diarrhoea morbidity, malassimilation and failure to thrive.
Vienna, Austria, 2000. Report of the First Research Coordination Meeting, International Atomic Energy Agency, NAHRES-56. p.26-30


2000 Uauy R, Vio F, Diaz E, Castillo Duran C, Cruchet S, Gotteland M, Hertrampf E, Mazariegos D, Olivares M, Pizarro F, Salazar G.
Application of isotopes in the development of nutrition policies and evaluation of interventions.
Vienna (Austria), 2000. International Atomic Energy Agency, IAEA - section of Nutritional and Health Related Environmental Studies, NARHES -58


Informes Nacionales

Monografías

Programas Informáticos

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