Troncoso Cotal Rodrigo Hernán

Profesor Asistente
Unidad Académica: 
Email: 
rtroncoso@inta.uchile.cl
Teléfono: 
(56) 229781486
Grado Académico: 
Doctor en Bioquímica, Universidad de Chile
Químico Farmacéutico, Universidad de Chile
Reseña: 

El estudio de los mecanismos moleculares de la acción de los glucocortioides y su relación con el desarrollo de enfermedades crónicas asociadas a la nutrición.

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Publicaciones

2016 Verdejo HE, Zalaquett R, Del Campo A, García L, Troncoso R, Marin A, Chiong M, Castro P, Lavandero S, Gabrielli L, Corbalán R. Atrial systolic function assessed by speckle tracking echocardiography is a good predictor of post-operative atrial fibrillation in elderly patients. Echocardiography 2016; 33(2):242-248
2016 Rodriguez JM, Monsalves-Alvarez M, Henriquez S, Llanos MN, Troncoso R. Glucocorticoid resistance in chronic diseases. Steroids. 2016; 115:182-192
2016 Pizarro M, Troncoso R, Martínez GJ, Chiong M, Castro PF, Lavandero S. Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity. Toxicology. 2016; 370:41-48
2016 Shaikh S, Troncoso R, Criollo A, Bravo-Sagua R, Morselli E, Garcia L, Quest AF, Cifuentes M, Hill JA, Lavandero S. Regulation of cardiomyocyte autophagy by calcium. Am J Physiol Endocrinol Metab 2016; 310:E587-E596
2016 Campos T, Ziehe J, Fuentes-Villalobos F, Riquelme O, Peña D, Troncoso R, Lavandero S, Morin V, Pincheira R, Castro AF. Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival. Biochim Biophys Acta 2016; 1863(6 Pt A):1200-1207
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A… et al. …Troncoso R. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016; 12(1):1-222
2016 Paredes F, Parra V, Torrealba N, Navarro-Marquez M, Gatica D, Bravo-Sagua R, Troncoso R, Pennanen C, Quiroga C, Chiong M, Caesar C, Taylor WR, Molgó J, San Martin A, Jaimovich E, Lavandero S. HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor. Free Radic Biol Med 2016; 90:206-218
2015 Niso-Santano M, Malik SA, Pietrocola F, Bravo-San Pedro JM, Mariño G, Cianfanelli V, Ben-Younès A, Troncoso R, Markaki M, Sica V, Izzo V, Chaba K, Bauvy C, Dupont N, Kepp O, Rockenfeller P, Wolinski H, Madeo F, Lavandero S, Codogno P, Harper F, Pierron G, Tavernarakis N, Cecconi F, Maiuri MC, Galluzzi L, Kroemer G. Unsaturated fatty acids induce non-canonical autophagy. EMBO J 2015; 34(8):1025-41
2015 Oyarzún AP, Westermeier F, Pennanen C, López-Crisosto C, Parra V, Sotomayor-Flores C, Sánchez G, Pedrozo Z, Troncoso R, Lavandero S. FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes. Biochem Pharmacol 2015;98(1):92-101
2015 Paredes F, Parra V, Torrealba N, Navarro-Marquez M, Gatica D, Bravo-Sagua R, Troncoso R, Pennanen C, Quiroga C, Chiong M, Caesar C, Taylor WR, Molgó J, San Martin A, Jaimovich E, Lavandero S. HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor. Free Radic Biol Med; 90:206-218
2014 Gutierrez T, Parra V, Troncoso R, Pennanen C, Contreras-Ferrat A, Vasquez-Trincado C, Morales PE, Lopez-Crisosto C, Sotomayor-Flores C, Chiong M, Rothermel BA, Lavandero S. Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocyte. Cell Commun Signal 2014;12(1):68
2014 Troncoso R, Paredes F, Parra V, Gatica D, Vázquez-Trincado C, Quiroga C, Bravo-Sagua R, Lopez-Crisosto C, Rodriguez AE, Oyarzún AP, Kroemer G, Lavandero S. Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance. Cell Cycle 2014;13(14):2281-95
2014 Troncoso R, Ibarra C, Vicencio JM, Jaimovich E, Lavandero S. New insights into IGF-1 signaling in the heart. Trends Endocrinol Metab 2014; 25(3):128-137
2014 Bravo R, Torrealba N, Paredes F, Morales PE, Pennanen C, López-Crisosto C, Troncoso R, Chiong M, Simmen T, Quest AF, Lavandero S. Organelle communication: signaling crossroads of homeostasis and disease. Int J Biochem Cell Biol 2014; 50:55-59
2014 Zepeda R, Kuzmicic J, Parra V, Troncoso R, Penannen C, Riquelme JA, Pedrozo Z, Chiong M, Sanchez G, Lavandero S. Drp1 loss-of-function reduces cardiomyocyte oxygen-dependence protecting the heart from ischemia-reperfusion injury. J Cardiovasc Pharmacol 2014; 63(6):477-487
2014 Parra V, Verdejo HE, Iglewski M, del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes 2014; 63(1):75-88
2014 del Campo A, Parra V, Gutiérrez T, Morales PE, López-Crisosto C,1 Vásquez-Trincado C, Bravo R, Verdejo HE, Contreras-Ferrat A, Troncoso R, Chiong M, Lavandero S. Mitochondrial fragmentation impairs insulin-dependent glucose uptake modulating Akt activity through mitochondrial Ca2+ uptake. Am J Physiol Endocrinol Metab 2014; 306(1):E1-E13
2013 Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J, Hill JA. Cardiovascular autophagy: Concepts, controversies and perspectives. Autophagy 2013; 3(9):1455-1466
2013 Quiroga C, Gatica D, Paredes F, Bravo-Sagua R, Troncoso R, Pedrozo Z, Rodriguez AE, Toro B, Chiong M, Vicencio JM, Hetz C, Lavandero S. Herp depletion protects from protein aggregation by up-regulation of autophagy. Biochim Biophys Acta 2013; 1833(2):3295-3305
2013 Troncoso R, Díaz-Elizondo J, Espinoza S, Navarro-Marquez M, Oyarzún AP, Riquelme JA, Garcia-Carvajal I, Díaz-Araya G, García L, Hill JA, Lavandero S. Regulation of cardiac autophagy by insulin-like growth factor 1. IUBMB Life 2013; 65(7):593-601.
2012 Verdejo HE, del Campo A, Troncoso R, Gutierrez T, Toro B, Quiroga C, Munoz JP, Garcia L, Castro PF, Lavandero S. Mitochondria, myocardial remodeling and cardiovascular disease. Curr Hypertens Rep 2012; 14(6):532-539
2012 Troncoso R, Vicencio JM, Parra V, Nemchenko A, Kawashima Y, Del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, Yakar S, Gillette TG, Hill JA, Abel ED, Leroith D, Lavandero S. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc Res 2012; 93(2):320-329
2012 Ayala P, Montenegro J, Vivar R, Letelier A, Aránguiz-Urroz P, Copaja M, Pivet D, Humeres C, Troncoso R, Vicencio JM, Lavandero S, Díaz-Araya G. Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol. Exp Mol Pathol 2012; 92(1):97-104
2011 Chiong M, Wang ZV, Pedrozo Z, Cao DJ, Troncoso R, Ibacache M, Criollo A, Nemchenko A, Hill JA, Lavandero S. Cardiomyocyte death: mechanisms and translational implications. Cell Death Dis 2011; 22(2):e244.
2011 Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci 2011; 124(13):2143-2152
2011 Aranguiz-Urroz P, Canales J, Copaja M, Troncoso R, Vicencio JM, Carrillo C, Lara H, Lavandero S, Díaz-Araya G. β2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation. Biochim Biophys Acta 2011; 1812(1):23-31
2010 Marambio P, Toro B, Sanhueza C, Troncoso R, Parra V, Verdejo H, García L, Quiroga C, Munafo D, Díaz-Elizondo J, Bravo R, González MJ, Diaz-Araya G, Pedrozo Z, Chiong M, Colombo MI, Lavandero S. Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes. Biochim Biophys Acta 2010; 1802(6):509-518
2010 Muñoz JP, Chiong M, García L, Troncoso R, Toro B, Pedrozo Z, Diaz-Elizondo J, Salas D, Parra V, Núñez MT, Hidalgo C, Lavandero S. Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide. Free Radic Biol Med 2010; 48(4):526-534
2010 Bittner A, Alcaíno H, Castro PF, Pérez O, Corbalán R, Troncoso R, Chiong M, Mellado R, Moraga F, Zanolli D, Winter JL, Zamorano JJ, Díaz-Araya G, Lavandero S. Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome. Int J Cardiol 2010; 143(1):98-100.
2009 Troncoso R, Moraga F, Castro PF, Chiong M, Mellado RM, Roldán J, Díaz-Araya G, Vukasovic JL, Greig D, Lavandero S. Gln27→Glu β2-adrenergic receptor polymorphism in heart failure patients: differential clinical and oxidative response to carvedilol. Basic Clin Pharmacol Toxicol 2009; 104(5):374-378.
2009 Aránguiz-Urroz P, Soto D, Contreras A, Troncoso R, Chiong M, Montenegro J, Venegas D, Smolic C, Ayala P, Thomas WG, Lavandero S, Díaz-Araya G. Differential participation of angiotensin II type 1 and 2 receptors in the regulation of cardiac cell death triggered by angiotensin II. Am J Hypertens 2009; 22(5):569-576
2009 Ribeiro CH, Molina MC, Aguilar L, Rodríguez M, Maldonado I, Valck C, Martínez R, González C, Troncoso R, Lavandero S, Gingras A, Schwaeble W, Ferreira A. Does Trypanosoma cruzi calreticulin have a role in Chagas’ disease autoimmunity?. Mol Immunol 2009; 46(6):1092-1099
2009 Eisner V, Criollo A, Quiroga C, Olea-Azar C, Santibañez JF, Troncoso R, Chiong M, Díaz-Araya G, Foncea R, Lavandero S. Hyperosmotic stress-dependent NFkappaB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes. FEBS Lett 2006; 580(18):4495-4500.
2009 Castro PF, Mc-Nab P, Bittner A, Greig D, Quintana JC, Vergara I, Corbalan R, Vukasovic JL, Chiong M, Copaja M, Diaz-Araya G, Troncoso R, Alcaino H, Lavandero S. Effects of carvedilol upon intra and interventricular syncrony in patients with chronic heart failure. Am J Cardiol 2005; 96:267-269.
2004 Castro P, Perez O, Greig D, Diaz-Araya G, Moraga F, Chiong M, Troncoso R, Padilla I, Vukasovic JL, Corbalan R, Lavandero S. Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress in patients with chronic heart failure. Rev Esp Cardiol 2004; 57:1053-1058
2010 Castro P, Gabrielli L, Verdejo H, Greig D, Mellado R, Concepción R, Sepúlveda L, Vukasovic JL, García L, Pizarro M, Pivet D, Carrillo C, Tapia F, Navarro M, Troncoso R, Baraona F, Llevaneras S, Hernández C, Godoy I, Jalil JE, Quintana JC, Orellana P, Chiong M, Lavandero S. Heart energy metabolism and its role in the treatment of heart failure]. Rev Med Chil. 2010 Aug;138(8):1028-39.
2010 Castro P, Gabrielli L, Verdejo H, Greig D, Mellado R, Concepción R, Sepúlveda L, Vukasovic JL, García L, Pizarro M, Pivet D, Carrillo C, Tapia F, Navarro M, Troncoso R, Baraona F, Llevaneras S, Hernández C, Godoy I, Jalil JE, Quintana JC, Orellana P, Chiong M, Lavandero S. Heart energy metabolism and its role in the treatment of heart failure]. Rev Med Chil. 2010 Aug;138(8):1028-39.
2008 Moraga F, Troncoso R, Mellado RM, Díaz-Araya G, Vukasovic JL, Greig D, Pérez O, García L, Roldán J, Ocaranza MP, Jalil J, Chiong M, Castro P. Interacción entre los polimorfismos del receptor β1 y β2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica. Rev Med Chil. 136(11):1371-80, 2008.
2006 Aránguiz P, Contreras A, Rojas D, Troncoso R, Marambio P, Toro B, Sanhueza C, Penannen C, Díaz-Elizondo J, Parra V, Chiong M, Díaz-Araya G, Lavandero S. Autofagia del cardiomiocito: ¿un nuevo mecanismo de adaptación al estrés o de muerte celular?. Rev Chil Cardiol 25:331-338, 2006.
2005 Castro P, Greig D, Copaja M, Alcaíno H, Troncoso R, Chiong M, Mellado R, Pérez O, Vukasovic JL, Díaz-Araya G, Corbalán R, Ocaranza MP, Jalil J, Lavandero S. Polimorfismos de los receptores β-adrenérgicos y su relación con el riesgo de insuficiencia cardiaca, etiología y prevalencia de infarto al miocardio. Rev Chil Cardiol 24: 38-47, 2005.
2005 Castro P, Mc-Nab P, Quintana JC, Bittner A, Greig D, Vergara I, Vukasovic JL, Corbalan R, Copaja M, Diaz-Araya G, Chiong M, Troncoso R, Alcaino H, Lavandero S. Efecto del carvedilol sobre la sincronía ventricular en pacientes con insuficiencia cardiaca congestiva. Rev Chil Cardiol 24: 132-137, 2005.
2005 Bittner A, Castro P, Pérez O, Corbalán R, Troncoso R, Chiong M, Díaz-Araya, Vicencio JM, Moraga F, Zanolli D, Winter JL, Zamorano JJ, Lavandero S. Inflamación y estrés oxidativo en el síndrome coronario agudo: ¿dos fenómenos relacionados?. Boletín de la Escuela de Medicina. 20: 6-11, 2005.
2005 Castro P, Lavandero S, Greig D, Copaja M, Alcaíno H, Troncoso R, Chiong M, Mellado R, Pérez O, Vukasovic JL, Díaz-Araya G, Corbalán R, Ocaranza MP, Jalil J. Polimorfismos de los receptores ß-adrenérgicos determinan el riesgo y etiología de la insuficiencia cardíaca. Boletín de la Escuela de Medicina 20: 12-18, 2005.
2014 Troncoso R, Verdejo HE, Quiroga C, Pedrozo Z, Corbalan R, García L. Autophagy in the onset of atrial fibrillation. AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Chapter 12. Autophay in the Onset of Atrial Fibrillation .Elsevier. Volume 5, 2014.
2012 Troncoso R, Vásquez-Trincado C, del Campo A, Gatica D, Morales P, Paredes F, Gutierrez T, Lopez-Crisosto C, Torrealba N, Garcia L, Diaz-Araya G, Battiprolu PK, Nemchenko A, Ferdous A, Gillette T, Hill JA, Lavandero S. Chapter 9. Regulation of autophagy by Insulin/IGF-1 signaling pathways. Autophagy: Principles, Regulation and Roles in Disease. Nova Publishers. 181-194, 2012.
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